alexa Lessons Learned from the TOPCAT Trial
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Editorial

Lessons Learned from the TOPCAT Trial

Wilbert S Aronow*
Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York, USA
Corresponding Author : Wilbert S Aronow
Cardiology Division
Department of Medicine
New York Medical College
Valhalla, New York 10595, USA
Tel: 914-493-5311
Fax: +358 3 364 1512
E-mail: [email protected]
Received January 16, 2015; Accepted January 20, 2015; Published January 22, 2015
Citation: Aronow WS (2015) Lessons Learned from the TOPCAT Trial . J Clin Exp Cardiolog 6:e138. doi:10.4172/2155-9880.1000e138
Copyright: © 2015 Aronow WS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Approximately half of patients with heart failure have a preserved left ventricular ejection fraction [1-5]. In sharp contrast to treatment of heart failure with reduced left ventricular ejection fraction, evidencebased drug therapies for treatment of heart failure with preserved left ventricular ejection fraction are still lacking [6]. The 3 major outcome trials performed in patients with heart failure and preserved left ventricular ejection fraction using inhibitors of the renin-angiotensin aldosterone system did not meet their primary endpoints [7-12].

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