Let-7 Family miRNAs Represent Potential Broad-Spectrum Therapeutic Molecules for Human CancerGuan J1,2*, Guo S3 and Liu M2
1Department of Scientific Research, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences (CAMS), Beijing 100730, China
2Department of Pathology, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences (CAMS), Beijing 100730, China
3Human and Health Scientific Data Sharing Platform, Clinical Center, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences (CAMS), Beijing 100730, China
- *Corresponding Author:
- Jian Guan
MD, Professor, Department of Scientific Research
Associate Professor, Department of Pathology, PUMC Hospital
CAMS/ PUMC, No.1, Shuaifuyuan Street, Dongcheng District
Beijing- 100730, China
E-mail: [email protected]
Received date: September 01, 2015; Accepted date: October 05, 2015; Published date: October 12, 2015
Citation: Guan J, Guo S, Liu M (2015) Let-7 Family miRNAs Represent Potential Broad-Spectrum Therapeutic Molecules for Human Cancer. J Genet Syndr Gene Ther 6: 271. doi:10.4172/2157-7412.1000271
Copyright: © 2015 Guan J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
miRNAs are a class of small non-coding RNAs that modulate gene expression. Let-7 was first discovered in Caenorhabditis elegans and is one of the most extensively studied miRNAs. The human let-7 family contains 13 miRNAs. The expression of these miRNAs is decreased in most human cancers and contributes to carcinogenesis and progression. Thus, the let-7 family of miRNAs has attracted the attention of researchers in various fields. Exogenous let-7 restoration has been confirmed to show antitumor efficacy in many human cancers. Let-7 functions as a tumor suppressor by acting upon several multi-signaling pathways and multiple downstream target oncogenes that are involved in most human cancers. Let-7 shows potential for modulation of chemoresistance and radiation sensitivity in human cancers. miRNAs in the let-7 family represent potential broad-spectrum antitumor molecules for human cancer therapy, and miRNAs in this family have been studied intensively for their therapeutic potential. However, most previous studies have been limited to a single functional aspect or focused on a single effect in a particular type of cancer. Here, we review the latest research on let-7 and discuss its potential value as a broadspectrum antitumor molecule.