Leukemia and the Peripheral Nervous System: A reviewWolfgang Grisold1*, Anna Grisold2, Johannes Hainfellner3 , Stefan Meng4and Christine Marosi5
- Corresponding Author:
- Dr. Wolfgang Grisold
Neurologist, Department of Neurology
KFJ hospital- Vienna, Austria1100 Vienna
Kundratstr. 3, Austria
E-mail: [email protected]
Received Date: April 14, 2014; Accepted Date: October 13, 2014; Published Date: October 16, 2014
Citation: Grisold W, Grisold A, Hainfellner J, Meng S, Marosi C (2014) Leukemia and the Peripheral Nervous System: A review. J Leuk (Los Angel) (Los Angel) 2:162. doi:10.4172/2329-6917.1000162
Copyright: © 2014 Grisold W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.d.
The fate of patients with leukemia has greatly improved in the past decades. Survival has been increased and the once stereotypic pattern of Cerebrospinal fluid (CSF) infiltration and diffuse infiltration of nerves and muscles has entirely changed.
Peripheral nervous structures as cranial nerves, nerve roots, plexus and peripheral nerves can be affected in different types of leukemia, by different mechanisms and at different time points.
Treatment side effects become more apparent, as the number of long term survivors increases. In some cases also isolated relapses of leukemia in the nervous system occurs and effects of stem cell transplantation on the nervous system became apparent.
Diagnostically the cranial nerves, nerve roots, cauda equina, nerve plexus and the peripheral nerves have become more accessible to investigation due to improved imaging methods as ultrasound and MRI, thus facilitating the earlier diagnosis and treatment of nerve involvement.