alexa
Reach Us +1-504-608-2390
Levosalbutamol versus Salbutamol for Treatment of Acute Exacerbation of Asthma in Bangladesh Children | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Levosalbutamol versus Salbutamol for Treatment of Acute Exacerbation of Asthma in Bangladesh Children

Atiar Rahman1*, Selina khanum1 and Simona Turcu2

1Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Bangladesh

2Evelina Children Hospital, London, UK

*Corresponding Author:
Atiar Rahman
Department of Pediatrics
Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh
E-mail: [email protected]

Received date: September 24, 2012; Accepted date: November 20, 2012; Published date: November 24, 2012

Citation: Rahman A, khanum S, Turcu S (2012) Levosalbutamol versus Salbutamol for Treatment of Acute Exacerbation of Asthma in Bangladesh Children. J Aller Ther 3:123. doi: 10.4172/2155-6121.1000123

Copyright: © 2012 Rahman A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Salbutamol is an effective treatment of acute exacerbation asthma but its use is associated with undesirable side effects like tachycardia and hypokalemia. Published studies have showed that levosalbutamol improves pulmonary function more than racemic salbutamol without the known salbutamol side effects.

Objective: To compare the efficacy and tolerability of Levosalbutamol and Salbutamol for the treatment of acute exacerbation of asthma in Bangladesh children aged 8 to 15 years.

Methods: A randomized double blind clinical study included 60 known asthmatic children aged between 8 and 15 years, who attended the emergency department for an acute exacerbation. The studied medicines were salbutamol 2.5 mg and levosalbutamol 0.63 mg. The total drug volume was 2.5 ml which was nebulized over a period of 8-10 minutes. Forced expiratory volume in 1st second was measured using Manual Promoter. Spirometry was performed 3 times and the best of the three values was recorded. The following clinical parameters were recorded initially and after giving 3 nebulizations at 20 minutes interval in the 1st hour of presentation: respiratory rate (RR), heart rate (HR), oxygen saturation in room air SPO2, FEV1 (forced expiratory volume in 1st second), asthma score and serum potassium level.

Results: In the levosalbutamol group there was significant increment in FEV1 and SpO2 (p<0.05) with decreased tachypnea and asthma score while no significant difference was found in the pre and post treatment HR and serum K+ levels. In the Salbutamol group although there was clinical improvement in terms of FEV1, SpO2 and asthma score, there was significant tachycardia and decrease in K+ levels.

Conclusion: Levosalbutamol has similar therapeutic effects with salbutamol in acute exacerbation of asthma but has no side effects such as tachycardia and hypokalemia.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

https://www.gaziantepescort.info

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version