alexa Lignans from the Leaves of Meliosma lepidota ssp. squam
e-ISSN: 2321-6182 p-ISSN: 2347-2332

Research & Reviews: Journal of Pharmacognosy and Phytochemistry
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Research Article

Lignans from the Leaves of Meliosma lepidota ssp. squamulata and their Biological Activity toward Leishmania major

Mio Iwami1, Susumu Kawakami2, Sachiko Sugimoto1, Katsuyoshi Matsunami1, Hideaki Otsuka1*, Tsutomu Mizuta3, Takakazu Shinzato4

1Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan

2Faculty of Pharmacy, Yasuda Women's University; 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731- 0153, Japan

3Graduate School of Sciences, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan

4Subtropical Field Science Center, Faculty of Agriculture, University of the Ryukyus; 1 Senbaru, Nishihara-cho, Nakagami-gun, Okinawa 903-0213, Japan

Corresponding Author:
Hideaki Otsuka
Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
E-mail: [email protected]

Received: 28/09/2015 Accepted: 02/11/2015 Published: 10/11/2015

 

Abstract

From the leaves of Meliosma lepidota ssp. squamulata, one new sesamintype lignan was isolated. Its structure was first elucidated by spectroscopic investigation and then finally determined by X-ray crystallographic analysis. The anti-Leishmania activity of the new lignan and related ones, (+)-aptosimon, (+)-sesamin and (+)-paulownin, isolated from this plant was evaluated.

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