Lignans from the Leaves of Meliosma lepidota ssp. squamulata and their Biological Activity toward Leishmania majorMio Iwami1, Susumu Kawakami2, Sachiko Sugimoto1, Katsuyoshi Matsunami1, Hideaki Otsuka1*, Tsutomu Mizuta3, Takakazu Shinzato4
- Corresponding Author:
- Hideaki Otsuka
Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
E-mail: [email protected]
Received: 28/09/2015 Accepted: 02/11/2015 Published: 10/11/2015
From the leaves of Meliosma lepidota ssp. squamulata, one new sesamintype lignan was isolated. Its structure was first elucidated by spectroscopic investigation and then finally determined by X-ray crystallographic analysis. The anti-Leishmania activity of the new lignan and related ones, (+)-aptosimon, (+)-sesamin and (+)-paulownin, isolated from this plant was evaluated.