alexa Limb Salvage Strategy by Intra-Arterial Chemotherapy fo
ISSN: 2167-7700

Chemotherapy: Open Access
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Research Article

Limb Salvage Strategy by Intra-Arterial Chemotherapy for Local Recurrent Osteosarcoma in Extremities

Cheng Liu1*, Jun Guo1, Fan Xiong1, Qiu Cui1, Dingfeng Li1, Yanjun Zeng2

1Department of Orthopedics, The Affiliated Hospital of Academy of Military Medical Sciences, PLA 307th Hospital, Beijing 100071, China

2Biomechanics and Medical Information Institute, Beijing, University of Technology, Beijing 100022, China

*Corresponding Author:
Yanjun Zeng
Biomechanics and Medical Information Institute
Beijing, University of Technology
Beijing 100022, China
Tel: +86-10-13521069552
Email: [email protected]

Received date: November 10, 2015 Accepted Date: December 15, 2015 Published Date: December 20, 2015

Citation: Cheng Liu (2015) Limb Salvage Strategy by Intra-Arterial Chemotherapy for Local Recurrent Osteosarcoma in Extremities. Chemo Open Access 5:176. doi: 10.4172/2167-7700.1000176

Copyright: © 2015 Cheng Liu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract Objective: The feasibility of intra-arterial chemotherapy for local recurrent extremity osteosarcoma with prosthesis replacement. Methods: 9 local recurrent limb osteosarcoma patients with prosthesis replacement who received treatment during the period from April 2010 to June 2013 at our hospital were recruited, including 3 patients with lung metastasis. All patients were treated with intra-arterial chemotherapy via implanted pump at affected limb. Results: The local recurrent neoplasms calcified and formed clear boundary with normal tissues after 3 to 5 cycles intra-arterial intervention chemotherapy, which indicates the osteosarcoma was controlled effectively to facilitate the osteosarcoma excision. No local recurrence happened during the follow-up visit varied from 12 to 38 months. The late result was better in 6 patients without lung metastasis than 3 patients with lung metastasis, 2 of who died and 1 currently survive without tumor. Conclusion: Intra-arterial intervention chemotherapy could effectively curb the progress of local recurrent osteosarcoma to facilitate the subsequent limb salvage treatment, and prolong the lifetime of patients with lung metastasis.


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