alexa Lipidomic Analysis of Serum from Horses with Strongyle Infection
ISSN: 2157-7579

Journal of Veterinary Science & Technology
Open Access

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Research Article

Lipidomic Analysis of Serum from Horses with Strongyle Infection

Jenna Lamb1, Gayle D. Hallowell1, Patricia Harris1,2*, Xing-Quan Zhu3 and Hany M. Elsheikha1*

1Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire, United Kingdom

2WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, Melton Mowbray Division of Veterinary Medicine, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus,Leicestershire, LE14 4RT, United Kingdom.

3State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China

*Corresponding Author:
Hany M. Elsheikha
Division of Veterinary Medicine, School of Veterinary Medicine and Science
Faculty of Medicine and Health Sciences
University of Nottingham, Sutton Bonington Campus
Leicestershire, United Kingdom
Tel: 0044-0115-951-6445
Fax: 0044-0115-951-6440
E-mail: [email protected]
 
Patricia Harris
WALTHAM Centre for Pet Nutrition
Waltham-on-the-Wolds
Melton Mowbray Division of Veterinary Medicine
School of Veterinary Medicine and Science
Faculty of Medicine and Health Sciences
University of Nottingham, Sutton Bonington Campus
Leicestershire, LE14 4RT, United Kingdom
E-mail: [email protected]

Received date: August 20, 2012; Accepted date: September 17, 2012; Published date: September 20, 2012

Citation: Lamb J, Hallowell GD, Harris P, Zhu XQ, Elsheikha HM (2012) Lipidomic Analysis of Serum from Horses with Strongyle Infection. J Vet Sci Technol 3:122. doi:10.4172/2157-7579.1000122

Copyright: © 2012 Lamb J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The development of techniques capable of accurate diagnosis of strongyle infections is at the forefront of research in equine parasitology. The aim of this study was to evaluate the potential, for using lipidomics in the diagnosis of strongyle infection. Blood and fecal samples were collected from 30 horses. Fecal egg count (FEC) results were used to select the serum samples from six uninfected horses (negative controls) and from the five horses with the highest burdens. The lipid portion of serum samples was extracted and analyzed using High Performance Liquid Chromatography-Mass Spectroscopy. The concentrations of 66 lipid metabolites differed between infected and uninfected horses (p<0.025). Database comparison of mass/charge (m/z) ratios and retention times were used to tentatively identify 16 of these metabolites. The roles of these metabolites and reasons for the observable changes were discussed. These results demonstrate the potential for the use of high resolution lipidomic analysis, for the development of a diagnostic technique capable of detecting, and perhaps stratifying, equine strongyle infection.

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