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Lipid-rich Glomerular Capillary Thrombi, of a Patient with Waldenstromand#8217;s Macroglobulinemia | OMICS International | Abstract
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Case Report

Lipid-rich Glomerular Capillary Thrombi, of a Patient with Waldenstrom’s Macroglobulinemia

Masanobu Gunji1, Itaru Ebihara1*, Megumi Koda1, Yuki Okubo1, Chihiro Sato1, Joichi Usui2, Kunihiro Yamagata2, Masaki Kobayashi3 and Takao Saito4

1Department of Nephrology, Mito Saiseikai General Hospital, Mito, Japan

2Department of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

3Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan

4General Medical Research Center, Faculty of Medicine, University of Fukuoka, Fukuoka, Japan

Corresponding Author:
Dr Ebihara Itaru
Department of Nephrology
Mito Saiseikai General Hospital
Futabadai, Mito, Ibaraki, Japan
Tel: +81-29-254-5151
Fax: +81-29-254-0502
E-mail: [email protected]

Received Date: February 24, 2017; Accepted Date: March 03, 2017; Published Date: March 08, 2017

Citation: Gunji M, Ebihara I, Koda M, Okubo Y, Sato C, et al. (2017) Lipid-rich Glomerular Capillary Thrombi, of a Patient with Waldenstrom’s Macroglobulinemia. J Hematol Thrombo Dis 5:263. doi:10.4172/2329-8790.1000263

Copyright: © 2017 Gunji M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


A 77-year-old woman was diagnosed nephrotic syndrome with Waldenström’s macroglobulinemia (WM). Renal biopsy revealed MPGN-like lesions with extensive glomerular capillary thrombi which were positive for anti-IgM and anti-lambda-light chain immunofluorescence. The electron microscopy showed characteristic thrombi intra glomerular capillary walls which were occupied with a lot of vacuoles. These structures were similar with them of lipoprotein glomerulopathy. The patient was started to treat with R-CHOP, and then nephrotic syndrome and her renal insufficiency were completely recovered. There were no previous reports of nephrotic syndrome and acute renal failure caused by oil-rich intracapillary thrombi in WM in the literature.


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