Lipid-rich Glomerular Capillary Thrombi, of a Patient with Waldenstrom’s MacroglobulinemiaMasanobu Gunji1, Itaru Ebihara1*, Megumi Koda1, Yuki Okubo1, Chihiro Sato1, Joichi Usui2, Kunihiro Yamagata2, Masaki Kobayashi3 and Takao Saito4
- Corresponding Author:
- Dr Ebihara Itaru
Department of Nephrology
Mito Saiseikai General Hospital
Futabadai, Mito, Ibaraki, Japan
E-mail: [email protected]
Received Date: February 24, 2017; Accepted Date: March 03, 2017; Published Date: March 08, 2017
Citation: Gunji M, Ebihara I, Koda M, Okubo Y, Sato C, et al. (2017) Lipid-rich Glomerular Capillary Thrombi, of a Patient with Waldenstrom’s Macroglobulinemia. J Hematol Thrombo Dis 5:263. doi:10.4172/2329-8790.1000263
Copyright: © 2017 Gunji M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A 77-year-old woman was diagnosed nephrotic syndrome with Waldenström’s macroglobulinemia (WM). Renal biopsy revealed MPGN-like lesions with extensive glomerular capillary thrombi which were positive for anti-IgM and anti-lambda-light chain immunofluorescence. The electron microscopy showed characteristic thrombi intra glomerular capillary walls which were occupied with a lot of vacuoles. These structures were similar with them of lipoprotein glomerulopathy. The patient was started to treat with R-CHOP, and then nephrotic syndrome and her renal insufficiency were completely recovered. There were no previous reports of nephrotic syndrome and acute renal failure caused by oil-rich intracapillary thrombi in WM in the literature.