alexa Lipocalin 2 Level Predicts Prognostic Outcome in Patients with Colorectal Cancer Undergoing Surgical Intervention | OMICS International | Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Lipocalin 2 Level Predicts Prognostic Outcome in Patients with Colorectal Cancer Undergoing Surgical Intervention

Chia-Lo Chang1, Yung-Lung Chen2, Yen-Ta Chen3, Steve Leu4, Li-Teh Chang5, Chang-Han Chen4, Chien-Chang Lu1, Wang-Hseng Hu1, Ko-Chao Lee1, Kai-Lung Tsai1, Hsueh-Wen Chang6, Hong-Hwa Chen1* and Hon-Kan Yip2,4,7*

1Division of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

2Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

3Division of Urology, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

4Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

5Basic Science, Nursing Department, Meiho University, Pingtung, Taiwan

6Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

7Center of Shock Wave Medicine and Tissue Engineering, Taiwan

*Corresponding Authors:
Hong-Hwa Chen
Division of Colorectal Surgery, Department of Surgery
Kaohsiung Chang Gung Memorial Hospital and
Chang Gung University College of Medicine, Kaohsiung, Taiwan
Tel: 886-7-7317123 ext: 2363 or 8300
E-mail: [email protected]
Hon-Kan Yip
Division of Cardiology, Department of Internal Medicine
Kaohsiung Chang Gung Memorial Hospital and
Chang Gung University College of Medicine, Kaohsiung, Taiwan
E-mail: [email protected]

Received Date: December 11, 2013; Accepted Date: Januauary 15, 2014; Published Date: Januauary 21, 2014

Citation: Chang CL, Chen YL, Chen YT, Leu S, Chang LT, et al. (2014) Lipocalin 2 Level Predicts Prognostic Outcome in Patients with Colorectal Cancer Undergoing Surgical Intervention. J Mol Biomark Diagn 5:162. doi:10.4172/2155-9929.1000162

Copyright: © 2014 Chang CL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study examined the predictive role of circulating lipocalin 2 in long-term prognostic outcome of Colorectal Cancer (CRC) patients with surgical intervention. 204 CRC patients with surgical intervention between April 2009 and May 2011 were prospectively enrolled. Circulating lipocalin 2 levels in CRC patients before surgery and healthy-control subjects were measured using ELISA. Patients were categorized into different CRC clinical stage (I to IV) based on pathological findings. Mean follow-up time was 21.2 ± 3.5 months. Patients were categorized into group 1 (n=67), lipocalin 2 levels <116.7 ng/ ml; and group 2 (n=137), lipocalin 2 levels ≥ 116.7 ng/ml by ROC curve analysis. CRC patients had higher circulating levels of lipocalin 2 than healthy subjects (P<0.0001). Occurrence of new metastases after surgery, primary (any cause of death or new metastasis) and secondary (CRC-related death and new metastasis) combined endpoint were higher in group 1 than group 2 (all P<0.03). Lower lipocalin 2 levels and CRC stage IV was independently predictive of primary and secondary combined endpoint (all P<0.001) during long-term follow-up. In conclusion, circulating lipocalin 2 level may be a useful biomarker for risk stratification of CRC patients during long-term follow-up.

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