alexa Lipoprotein Lipase Activation Improve the Cachexia and Obesity
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Lipoprotein Lipase Activation Improve the Cachexia and Obesity

Masataka Kusunoki1*, Kazuhiko Tsutsumi2, Chen Tana3, Daisuke Sato4 and Takao Nakamura4
1Department of Internal Medicine, Medical Clinic, Aichi Medical University, Nagoya, Japan
2Okinaka Memorial Institute for Medical Research, Tokyo, Japan
3Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan
4Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan
Corresponding Author : Masataka Kusunoki
Department of Internal Medicine
Medical Clinic, Aichi Medical University
2-12-1, Higashisakura, Higashi-ku
Nagoya 461-0005, Japan
Tel: +81-52-931-2261
Fax: +81-52-931-4841
E-mail: [email protected]
Received May 20, 2013; Accepted May 31, 2013; Published June 03, 2013
Citation: Kusunoki M, Tsutsumi K, Tana C, Sato D, Nakamura T (2013) Lipoprotein Lipase Activation Improves the Cachexia and Obesity. J Obes Weight Loss Ther 3:177. doi:10.4172/2165-7904.1000177
Copyright: © 2013 Kusunoki M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Cachexia is defined as an extreme wasting condition with marked weight loss. It is observed in paints with cancer and severe infectious disease. Obesity is one of the fasted growing major diseases in developed and developing countries. As has been persuasively argued, long-term imbalance between intake and expenditure of fat is a central factor in the etiology of obesity. We hypothesized that elevating lipoprotein lipase (LPL) activity would cause an improvement of cahexia and obesity. To test this hypothesis, we studied the effects of the LPL activator NO-1886 in cachexia and obese animals.

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