alexa Liposil Nanocarriers for Pharmaceutical Applications: Synthesis Innovations
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Liposil Nanocarriers for Pharmaceutical Applications: Synthesis Innovations

Gonçalves MC1,2*, Rodrigues AM3, Sabino A3, Corvo ML4 and Martins MB4

1Departamento de Engenharia Química, Instituto Superior Técnico, Universidade Lisboa, Lisboa, Portugal

2CQE, Centro de Química Estrutural, Lisboa, Portugal

3Departamento de Biongenharia, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

4iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal

*Corresponding Author:
Gonçalves MC
Departamento de Engenharia Química
Instituto Superior Técnico
Universidade Lisboa, Lisboa, Portugal
Tel: 351 966622774
E-mail: [email protected]

Received date: July 17, 2017; Accepted date: July 21, 2017; Published date: July 28, 2017

Citation: Gonçalves MC, Rodrigues AM, Sabino A, Corvo ML, Martins MB (2017) Liposil Nanocarriers for Pharmaceutical Applications: Synthesis Innovations. J Nanomed Nanotechnol 8: 450. doi: 10.4172/2157-7439.1000450

Copyright: © 2017 Gonçalves MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The unique characteristics of liposomes make them interesting vehicles for diagnostic performance. However, when oral administration is envisaged, the adjustment of liposomes surface chemistry is mandatory. Silica-coated liposomes, Liposils for short, become a promising route. In the present work a novel time-saving process is proposed for liposomes’ coating. Two sets of charged liposomes are prepared by lipid hydration and dimensioned through extrusion techniques. The first liposomes set are silica-coated with classical sol-gel Stöber protocol (and used as a reference) while in the second set a modified LaMer process is proved. The resulting Liposil structures are characterized by Dynamic Light Scattering (DLS), Zeta Potential (ζ), Transmission Electron Microscopy (TEM), Fourier Transformed Infrared (FTIR) spectroscopy, Near Infrared (NIR) spectroscopy.

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