alexa Literature Reviews on Methods for Rare Variant Associat
ISSN: 2161-0436

Human Genetics & Embryology
Open Access

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Review Article

Literature Reviews on Methods for Rare Variant Association Studies

Shurong Fang1*, Shuanglin Zhang2 and Qiuying Sha2

1Department of Mathematics, Fairfield University, Fairfield, CT 06824, USA

2Department of Mathematical Sciences, Michigan Technological University, Houghton, MI 49931, USA

*Corresponding Author:
Shurong Fang
Department of Mathematics, Fairfield University
Fairfield, CT 06824, USA
Tel: (203) 254-4184
E-mail: [email protected]

Received Date: February 01, 2016; Accepted Date: February 16, 2016; Published Date: February 18, 2016

Citation: Fang S, Zhang S, Sha Q (2016) Literature Reviews on Methods for Rare Variant Association Studies. Human Genet Embryol 6:133. doi:10.4172/2161-0436.1000133

Copyright: © 2016 Fang S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The widespread availability of genome sequencing data has yielded different rare variant association methods in population-based or family-based designs. However, it is challenging to know which method is appropriate in practice. Our purpose of this paper is to provide a general review of the literature for rare variant association studies and suggestions on future research directions. This paper discusses methods for recent rare variant association studies in three categories. The first two categories are for population-based designs, with/without considering the direction of the effects of causal rare variants. In the third category, methods for family-based designs are concluded.

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