Liver Abscesses in Dromedary Camels (Camelus dromedaries): Oxidative Stress Biomarkers and Proinflammatory CytokinesWael M El-Deeb1,2* and Taha A Fouda1,2
- *Corresponding Author:
- Wael M El-Deeb
Department of clinical studies
College of Veterinary Medicine and animal Resources
King Faisal University, Al-Ahsa
31982 P.O. Box: 1757, Saudi Arabia
Tel: (00966) (050) 9296154
Fax: (00966) (03) 5816635
E-mail: [email protected]
Received date: July 12, 2013; Accepted date: August 22, 2013; Published date: August 24, 2013
Citation: El-Deeb WM, Fouda TA (2013) Liver abscess in Dromedary Camels (Camelus dromedaries): Oxidative Stress Biomarkers and Proinflammatory Cytokines. J Veterinar Sci Technol 4:140. doi:10.4172/2157-7579.1000140
Copyright: © 2013 El-Deeb WM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: The characteristic clinical manifestations, oxidative stress markers and proinflammatory Cytokines in liver abscess in camel are poorly defined.
Objective: The objectives of this study were to investigate liver abscess in camel at the slaughter house and to address its effect on blood cellular and biochemical values particularly oxidative stress markers and proinflammatory cytokines.
Methods: Thirty-five camels with liver abscess and 15 healthy camels were included in this study. Complete blood picture, and selected biochemical parameters were carried out. Bacteriological examination was also carried out.
Results: Clinical signs were recorded. The hematological picture of diseased camels revealed reduction in the total erythrocytic count and hemoglobin level associated with elevation in leucocytic count and neutrophils percentage. The biochemical analysis of serum samples revealed increase in the levels of liver enzymes associated with reduction in the levels of total proteins, albumen and glucose levels in diseased camels when compared to their levels in healthy ones. Increased levels of lipid peroxidation and glucose 6-phosphate dehydrogenase with significant reduction in the levels of superoxide dismutase, catalase and glutathione were evident when compared to their levels in healthy camels. There was elevation in the levels of TNF-α, IFN-γ, IL-1α, IL-1β, IL-6 and IL-10 in diseased camels when compared to their levels in normal ones. The isolated bacteria from liver abscess were Fusobacterium necrophorum, Corynebacterium psuedotuberclosis, Escherichia coli, and Staphylococcus spp.
Conclusions: Oxidative stress and proinflammatory Cytokines could be used as biomarkers of liver abscess in camel.