alexa Living Donor Liver Transplantation for Patients with Pre-existent Portal Vein Thrombosis
ISSN: 2167-0889

Journal of Liver
Open Access

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Research Article

Living Donor Liver Transplantation for Patients with Pre-existent Portal Vein Thrombosis

Hazem M Zakaria1, Mohammad Taha1, Emad Hamdy Gad1, Hossam El-Deen Soliman1, Osama Hegazy1, Talaat Zakareya2, Mohamed Abbasy2, Dina Elazab3, Doha Maher3, Rasha Abdelhafiz4, Hazem Abdelkawy4, Nahla K Gaballa5, Khaled Abou El-Ella1 and Tarek Ibrahim1

1Department of Hepatopancreatobiliary and Liver Transplant Surgery, National Liver Institute, Menoufia University, Menoufia, Egypt

2Department of Hepatology and Gastroentrology, National Liver Institute, Menoufia University, Menoufia, Egypt

3Department of Pathology, National Liver Institute, Menoufia University, Menoufia, Egypt

4Department of Diagnostic and intervention radiology, National Liver Institute, Menoufia University, Menoufia, Egypt

5Department of Anesthesia and Intensive Care, National Liver Institute, Menoufia University, Menoufia, Egypt

*Corresponding Author:
Hazem Zakaria
National Liver Institute, Menoufia University
Shebin El-koom, Menoufia, Egypt
Tel: +201097071055
E-mail: [email protected]

Received date: May 25, 2017; Accepted date: June 5, 2017; Published date: June 8, 2017

Citation: Zakaria HM, Taha M, Gad EH, Soliman HE, Hegazy O, et al. (2017) Living Donor Liver Transplantation for Patients with Pre-existent Portal Vein Thrombosis. J Liver 6:214. doi: 10.4172/2167-0889.1000214

Copyright: © 2017 Zakaria HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Portal vein thrombosis (PVT) in living donor liver transplantation (LDLT) is a surgical challenge with technical difficulty. The aim of this study was to analyze the operative planning for management of PVT in LDLT and the impact of PVT on the outcome in comparison to patients without PVT. Methods: Between July 2003 to August 2016, 213 patients underwent LDLT. The patients were divided into two groups with and without PVT. The preoperative, operative, and postoperative data were analysed. Results: Thirty six patients (16.9%) had different grades of PVT at time of liver transplantation (LT); grades I, II, III and IV were 18 (50%), 14 (38.9%), 3 (8.3%) and 1 patient (2.8%) respectively. The management of PVT was by; thrombectomy in 31 patients (86%), bypass graft in 2 patients (5.6%), portal replacement graft in 1 patient (2.8%), anastomosis with the left renal vein in 1 patient (2.8%) and with large collateral vein in 1 patient (2.8%). Overall postoperative PVT occurred in 10 patients (4.7%), 4 patients of them had preoperative PVT. The perioperative mortality in patients with PVT, and patients without PVT was 33.3%, and 20.3%, respectively (P=0.17). The 1-, 3-, 5-, and 7y survival in patients with PVT was 49.7%, 46.2%, 46.2%, 46.2% respectively and in patients without PVT it was 65%, 53.7%, 50.8%, 49% respectively (P=0.29). Conclusions: Preoperative PVT may not keep a patient from undergoing successful LT with comparable outcome to patients without PVT specially with partial PVT.

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