Nina Hauptman and Damjan GlavaÄÃÂ
Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides in length with limited protein coding potential were found to be pervasively transcribed and are associated with tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. lncRNAs are found to be differentially expressed in various cancers and associated with cancer development and progression, revealing their potential for diagnostic and prognostic biomarkers in cancer. In this review, we will summarize the most important lncRNAs, focusing on their diagnostic and prognostic potential in different cancers.
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