alexa Long Term Outcomes of Kidney Transplant: Characteristic
ISSN: 2472-4971

Journal of Medical & Surgical Pathology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Long Term Outcomes of Kidney Transplant: Characteristics of Recipients with 20 or More Years of Graft Survival

Gaetano La Manna1*, Irene Capelli1, Lorenzo Gasperoni1, Giorgia Comai1, Matteo Ravaioli2, Antonio Marchetti3, Paola Rucci3, Giovanni Liviano D’Arcangelo1, Stefano Faenza4, Antonio Daniele Pinna2 and Maria Piera Scolari1

1Department of Experimental, Diagnostic and Specialty Medicine, Dialysis, Nephrology and Transplantation Unit, S. Orsola Hospital, University of Bologna, Italy

2Department of General Surgery and Transplantation, S. Orsola Hospital, University of Bologna, Italy

3Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Italy

4Department of Anaesthesia, Analgesia and Intensive Care, S. Orsola University Hospital, Bologna, Italy

*Corresponding Author:
Gaetano La Manna
Department of Experimental, Diagnostic and Specialty Medicine Dialysis
Nephrology and Transplantation Unit S. Orsola Hospital, University of Bologna
Bologna, Italy
Tel: +39 051 636 4577
Fax: +39 051 34 44 39
E-mail: gaetano.lamanna@unibo.it

Received Date: Jan 06, 2016 Accepted Date: Mar 03, 2016 Published Date: Mar 07, 2016

Citation: Manna GL,Capelli I, Gasperoni L,Comai G, Ravaioli M, et al. (2016) Long Term Outcomes of Kidney Transplant: Characteristics of Recipients with 20 or More Years of Graft Survival. J Med Surg Pathol 1:109.doi: 10.4172/jmsp.1000109

Copyright: © 2016 Manna GL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: Kidney transplant survival in the first year after transplantation has significantly improved, although long-term results are less encouraging. In recent years the pressure on the scientific community on the need to refine methods to discover the possible factors that can predict graft survival after 10, 20 years or more after transplantation is increased. Few previous studies have evaluated patient and laboratory characteristics associated with optimal long-term graft survival. The objective of this study was to identify possible factors associated with the survival of the transplanted kidney in the very long term. Methods: We retrospectively studied adults who had received first-time, single kidney transplants between 1967 and 1991 at S. Orsola Hospital in Kidney Transplant Centre in Bologna. We compared the clinical, immunological, and laboratory profile of patients whose grafts were still functioning ≥ 20 years after kidney transplantation to those whose transplants survived <20 years. Results: We identified 111 patients (24.5%) who received transplants with a functioning graft for 20 or more years after transplantation. Female gender, living donor, younger donor age, shorter delayed graft function duration (DGF), lower one-year creatinine and higher one-year eGFR predicted ≥ 20-year functional graft survival in the univariate analyses. In the multivariate analysis, only female gender, shorter DGF duration and 1-year creatinine and eGFR remained as significant predictors of graft survival ≥ 20 years. Conclusions: To our knowledge, this is the first report of 20-year graft survival being associated with one-year renal function. Accordingly, efforts should be targeted to preserving graft function in the first year after kidney transplantation. In addition we have identified a population of long-term kidney transplants survivors who will be the subject of further studies in order to clarify mechanism of immunological tolerance to transplant.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords