alexa Long Term Survival of a Patient with Metastatic Renal Cell Carcinoma Treated with Half-Dose Pazopanib: A Case Report
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Long Term Survival of a Patient with Metastatic Renal Cell Carcinoma Treated with Half-Dose Pazopanib: A Case Report

Giada Cortese1*, Maria Teresa Martino1, Elisabetta Gambale1, Clara Natoli2 and Michele De Tursi3
1Department of Oncology, Hospital via dei Vestini, Italy
2Medical Oncology Unit, Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio, Italy
3Department of Medical, Oral and Biotechnological Sciences, University G. d’Annunzio, Italy
Corresponding Author : Giada Cortese
Department of Oncology, Hospital via dei Vestini, Italy
Tel: 0871358005
Fax: 0871358476
E-mail: [email protected]
Received: October 13, 2015 Accepted: December 13, 2015 Published: December 21, 2015
Citation: Cortese G, Martino MT, Gambale E, Natoli C, De Tursi M (2015) Long Term Survival of a Patient with Metastatic Renal Cell Carcinoma Treated with Half-Dose Pazopanib: A Case Report. J Clin Case Rep 5:658. doi:10.4172/2165-7920.1000658
Copyright: © 2015 Cortese G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

We describe the case of a 59-year-old woman who underwent a radical left nephrectomy for renal cell cancer in 1993. After 7 years, the disease relapsed as thyroid and pulmonary metastases and she has been initially treated with chemotherapy. At further progression we administered an antiangiogenic drug, Sunitinib for 9 months then we switched to Pazopanib. The patient is still receiving a half-dose of Pazopanib (46 months) and she is showing a longlasting response with an optimal safety profile. In this patient, Pazopanib demonstrated a significant improvement in PFS and tumor response also with half a dose. Nephrectomy, metastasectomy, medical therapy and targeted treatments have been shown able to prolong survival and improve quality of life. This is an example of chronicized disease in a patient who can be defined as a long-term survivor.

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