alexa Long-term Follow-up of Pegylated Liposomal Doxorubicin and Oxaliplatin in Recurrent Ovarian Cancer
ISSN: 2329-6771

Journal of Integrative Oncology
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Research Article

Long-term Follow-up of Pegylated Liposomal Doxorubicin and Oxaliplatin in Recurrent Ovarian Cancer

Francesco Recchia1,2*, Giampiero Candeloro1 and Silvio Rea2,3

1Operational Oncology unit, Ospedale Civile di Avezzano, Italy

2Fondazione “Carlo Ferri”, Monterotondo, Roma, Italy

3Oncology surgery, University of L’Aquila, Italy

*Corresponding Author:
Francesco Recchia
Operational Oncology unit, Ospedale Civile di Avezzano
Fondazione “Carlo Ferri”, Monterotondo, Roma, Italy
Tel: +39 863 52119
E-mail: [email protected]

Received date: March 13, 2016; Accepted date: May 05, 2016; Published date: May 13, 2016

Citation: Recchia F, Candeloro G, Rea S (2016) Long-term Follow-up of Pegylated Liposomal Doxorubicin and Oxaliplatin in Recurrent Ovarian Cancer. J Integr Oncol 5:166. doi:10.4172/2329-6771.1000166

Copyright: © 2016 Recchia F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Oxaliplatin (LOHP) and pegylated liposomal doxorubicin (PLD) are active single agents in recurrent ovarian cancer (ROC). In this phase II study we explored safety and activity of combined LOHP and PLD in the treatment of ROC. Eligible patients had had disease recurrence following a paclitaxel/ carboplatin regimen or following cisplatinum or non-platinum-based second line chemotherapy. Other eligibility criteria were a performance status ≤ 2 and a life expectancy > 3 months. Treatment consisted of 120 mg/m2 LOHP and 40 mg/m2 PLD, given over 2 days, every 3 weeks. Forty-six patients with ROC were entered into the study between 10/2001 and 10/2005; 67.5% of patients were platinum-sensitive. Toxicity was moderate, with grade 3 or 4 neutropenia in 2% of patients, and grade 2 PPE in 7% of patients. Overall response rate was 67.5%. Median progression-free survival (PFS) was 27.5 months, while median overall survival was 44 months. We conclude that LOHP and PLD are active in ROC, and can be safely administered in pre-treated patients

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