alexa Long-Term Outcomes of Recurrent Thymoma
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
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Research Article

Long-Term Outcomes of Recurrent Thymoma

Cai Xu1, Qinfu Feng1*, Zhouguang Hui1, Chengcheng Fan2, Yirui Zhai1, Yidong Chen3, Hongxing Zhang1, Zefen Xiao1, Jun Liang1, Dongfu Chen1, Zongmei Zhou1, Miaoli Zheng1, Xiaodan Wang1, Lvhua Wang1* and Jie He4

1Department of Radiation Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

2Department of Radiation Oncology, Cancer Hospital Affiliated to Zhengzhou University, Henan Province, China

3Department of Radiation Oncology, Beijing Shijitan Hospital, Beijing, China

4Department of Thorax Surgery, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

*Corresponding Authors:
Qin-Fu Feng
Department of Radiation Oncology
Cancer Hospital/Institute
Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, China
Tel: 0086-010-87788286
Fax; 0086-010-62108145
E-mail: [email protected]
Lvhua Wang
Department of Radiation Oncology
Cancer Hospital/Institute
Chinese Academy of Medical Sciences, and Peking Union Medical College
Beijing-100021, China
Tel: 0086-010-8778799
Fax; 0086-010-62108145 E-mail: [email protected]

Received date: July 09, 2016; Accepted date: September 15, 2016; Published date: September 19, 2016

Citation: Xu C, Feng Q, Hui Z, Fan C, Zhai Y, et al. (2016) Long-Term Outcomes of Recurrent Thymoma. J Pulm Respir Med 6:367. doi: 10.4172/2161-105X.1000367

Copyright: © 2016 Xu C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: This study sought to analyze the results and prognosis of recurrent thymoma. Methods: Between 1991 and 2012, 32 patients that developed recurring thymoma after radical resection at initial treatment were reviewed. Results: The median follow-up duration after initial treatment and recurrence was 89 and 49.5 months, respectively. The median recurrence free internal (RFI) was 42 months, and the 5-year overall survival (OS) rates following recurrence was 65.5% for recurrent thymoma. Among 32 patients that relapsed, 7 underwent reoperation, 18 experienced nonsurgical management, 5 failed to receive treatment, and 2 remain unknown. The 5-year OS rates after recurrence of the surgery plus adjuvant chemotherapy/radiotherapy group and the non-surgery group were 100% and 73.1%, respectively (P=0.210). Histological WHO upgrading was frequently observed (57.1%) in patients with recurrent thymoma who received reoperation. In univariate analysis, age (<55 years, P=0.009), local and regional recurrence (P=0.022), and late recurrence (RFI ≥ 20 months, P=0.038) indicated good prognostic factors of recurrent thymoma. Conclusions: Reoperation plus adjuvant chemotherapy/radiotherapy may result in good outcomes for patients who can tolerate surgery when complete resection is possible, and may get better results than non-surgery treatment. Histological WHO upgrade was frequently observed in recurrent thymoma. Age <55 years, local and regional recurrence, and longer RFI (RFI ≥ 20 months) were associated with a positive prognosis.

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