Long-Term Post-Treatment MR and PET/CT Imaging in Prostate Cancer Patients in Complete Remission after Curative Radiotherapy with or without Androgen Deprivation: The Image of CureRaymond Miralbell1,4, Hansjörg Vees1*, Osman Ratib2, Michael Wissmeyer2, Charles Steiner2, Yann Seimbille2, Haleem G. Khan3 and Franz Buchegger3
- Corresponding Author:
- Hansjörg Vees
Department of Radiation Oncology
Geneva University Hospital, CH-1211 Geneva 14, Switzerland
Tel: +41 22 3827090
Fax: +41 22 382711
E-mail: [email protected]
Received Date: May 02, 2011; Accepted Date: December 06, 2011; Published Date: December 08, 2011
Citation: Miralbell R, Vees H, Ratib O, Wissmeyer M, Steiner C, et al. (2011) Long-Term Post-Treatment MR and PET/CT Imaging in Prostate Cancer Patients in Complete Remission after Curative Radiotherapy with or without Androgen Deprivation: The Image of Cure. J Nucl Med Radiat Ther 2:118. doi:10.4172/2155-9619.1000118
Copyright: © 2011 Miralbell R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: To investigate the risk of false positive MRI and 18F-Fluorocholine (FCH) or 11Cacetate (AC) PET/ CT in prostate cancer patients with long term biochemical and clinical remission after curative radiation therapy (RT).
Methods and Materials: Twenty patients underwent MRI studies including T2-weighted, diffusion weighted, dynamic contrast-enhanced, and spectroscopic imaging. Nine of these patients were selected to have FCH and 10 AC PET/CT studies.
Results: MR spectroscopy suggested positive or equivocal results in 16/20 patients. However, the combined interpretation of all MRI sequences dropped the rate of suspicious or equivocal studies to 8/20. All but one patient underwent also PET/CT and early PET frames showed suspicious or equivocal local images in 15/19 patients (8/10 with AC, 7/9 with FCH). However, a combined evaluation of early and late PET frames was judged equivocal in only 1 patient.
Conclusions: Multimodal MRI, early single FCH or AC PET frames of the prostate after curative RT may not be accurate enough to differentiate remission from early recurrence. Multiple-phase evaluation of PET images, however, may reduce significantly the risk of reporting equivocal or false positive results.