Loss of Rare Recessive Lethal Alleles due to Consanguineous Marriages in Inbred PopulationsArindam RoyChoudhury*
Department of Biostatistics, Columbia University, New York NY 10032, USA
- *Corresponding Author:
- Dr. Arindam RoyChoudhury
Department of Biostatistics
New York NY 10032, USA
E-mail: [email protected]
Received date: July 08, 2011; Accepted date: November 23, 2011; Published date: November 30, 2011
Citation: RoyChoudhury A (2011) Loss of Rare Recessive Lethal Alleles due to Consanguineous Marriages in Inbred Populations. J Biom Biostat 2:121. doi:10.4172/2155-6180.1000121
Copyright: © 2011 RoyChoudhury A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In a population practicing consanguineous marriage, rare recessive lethal alleles (RRLA) have higher chances of affecting phenotypes. As inbreeding causes more homozygosity and subsequently more deaths, the loss of individuals with RRLA decreases the frequency of these alleles. Although this phenomenon is well studied in general, here some hitherto unstudied cases are presented. An analytical formula for the RRLA frequency is presented for infinite monoecious population practicing several different types of inbreeding. In finite diecious populations, it is found that more severe inbreeding leads to quicker RRLA losses, making the upcoming generations healthier. A population of size 10,000 practicing 30% half-sib marriages loses more than 95% of its RRLA in 100 generations; a population practicing 30% cousin marriages loses about 75% of its RRLA. Our findings also suggest that given enough resources to grow, a small inbred population will be able to rebound while losing the RRLA.