alexa Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells

Raji Padmanabhan1, Kevin G Chen2 and Michael M Gottesman1*

1 Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

2 NIH Stem Cell Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA

Corresponding Author:
Michael M. Gottesman
Laboratory of Cell Biology
National Cancer Institute
National Institutes of Health
Bethesda, MD 20892, USA
Tel: 3014961530
Fax: 3014020450
E-mail: [email protected]

Received Date: February 12, 2014; Accepted Date: March 15, 2014; Published Date: March 17, 2014

Citation: Padmanabhan R, Chen KG, Gottesman MM (2014) Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells. J Stem Cell Res Ther 4:180. doi:10.4172/2157-7633.1000180

Copyright: © 2014 Padmanabhan R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The expression and function of the ATP-binding cassette (ABC) transporter ABCG2 have been studied for two decades in both adult and cancer stem cells. However, this important ABC transporter has not been well characterized in human embryonic stem cells (hESCs). Studies designed to understand the role of ABCG2 in hESCs are still in their initial stages. Several recent reports on expression patterns of the ABCG2 gene in hESCs contain contradictory results at both the mRNA and protein levels. In this review, we provide possible explanations for these discrepancies in ABCG2 expression patterns. We discuss micro-RNA-mediated regulatory roles in controlling ABCG2 mRNA stability and translation, which are associated with hESC pluripotency and differentiation.

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