alexa Low CD4 Counts and Early Sexual Debut Predict Genital C
ISSN: 2161-0517

Virology & Mycology
Open Access

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Research Article

Low CD4 Counts and Early Sexual Debut Predict Genital Cytomegalovirus Infection among HIV Infected Women in Mwanza, Tanzania

Fridolin Mujuni*1, Mariam M Mirambo*2, Muller Andreas3, Korn Klaus 4, Dismas Matovelo 1, Martha F Mushi2, Mtebe Majigo 5 and Stephen E Mshana2

1Department of Obstetrics and Gynecology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania

2Department of Microbiology and Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania

3Department of Tropical Medicine, Medical Mission Hospital, Salvatorstrasse 7, 97074, Wuerzburg, Germany

4Institute of Clinical and Molecular Virology, Enlargen University, Schlossgarten 491054 Erlangen, Germany

5Department of Microbiology and Immunology, Muhimbili University of Health and allied sciences, P.O. Box 65001, Dar es Salaam, Tanzania

*Corresponding Author:
Fridolin Mujuni
Department of Microbiology and Immunology
Weill Bugando School of Medicine
P.O.Box 1464, Mwanza, Tanzania
E-mail: [email protected]
Mariam M Mirambo
Department of Microbiology and Immunology
Weill Bugando School of Medicine
P.O.Box 1464, Mwanza, Tanzania
E-mail: [email protected]

Received date: February 15, 2016 Accepted date:March 07, 2016 Published date: March 17, 2016

Citation:Mujuni F, Mirambo MM, Andreas M, Klaus K, Matovelo D, et al. (2016) Low CD4 Counts and Early Sexual Debut Predict Genital Cytomegalovirus Infection among HIV Infected Women in Mwanza, Tanzania. Virol Mycol 5:155. doi:10.4172/2161-0517.1000155

Copyright: © 2016 Mujuni F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Objective: Here we report the prevalence and predictors of genital CMV infection among HIV infected women in Mwanza, Tanzania. Methods: A total of 255 HIV seropositive women were investigated between August and October, 2014. Demographic and clinical data were collected using standardized data collection tool. Exfoliated cells from endocervix were obtained and detection of CMV DNA was done using real-time polymerase chain reaction (RTPCR). Results: A total number of 255 HIV infected women were enrolled with the mean age of 39.2 ± 9.1.The overall prevalence of genital CMV among HIV infected women was 43(16.7%, 95% CI: 12-21). Inflammatory changes and dysplasia did not show any association with genital CMV infection (p>0.05). Only good socio-economic status (OR=2.36, 95% CI; 1.1-5.02, p=.0.027), young age at first sexual intercourse (OR=2.18, 95% CI; 1.04-4.62, p=0.04) and lower CD4+ counts (OR=2.07, 95% CI; 1.23-3.48, p=.0.027) were found to be independent predictors of genital CMV infection among HIV infected women. Conclusion: A significant proportion of HIV infected women are genitally infected with CMV in the genital tract. More studies to ascertain the clinical role of this virus in the female genital tract are recommended especially in HIV infected women.

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