Lower Plasma Zinc Levels in Hyperglycemic People Living with HIV in the MASH cohort
- *Corresponding Author:
- Alicia Sneij
Florida International University
Center for Research on US Latino
HIV/AIDS and Drug Abuse (CRUSADA), USA
E-mail: [email protected]
Received date: November 06, 2015; Accepted date: February 10, 2016; Published date: February 15, 2016
Citation: Sneij A, Campa A, Martinez SS, Stewart T, Baum M (2016) Lower Plasma Zinc Levels in Hyperglycemic People Living with HIV in the MASH cohort. J AIDS Clin Res 7:542. doi:10.4172/2155-6113.1000542
Copyright: © 2016 Sneij A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Zinc deficiency is prevalent in HIV and hyperglycemic patients. Antiretroviral therapy (ART) is a treatment to control HIV progression; however it increases the risk for hyperglycemia. The objective of this study was to assess the plasma zinc levels in hyperglycemic people living with HIV (PLWH).
Methods: Secondary analysis was conducted on the data from the Miami Adult Studies in HIV (MASH) cohort in Florida. Patients were categorized into hyperglycemic group (fasting blood glucose ≥100 mg/dL) and normal group (<100 mg/dL).
Results: Plasma zinc status and CD4 levels were lower in the hyperglycemic group, however the difference was not significant. There was a greater percentage of plasma zinc deficiency in the hyperglycemic group (69%) compared to the normoglycemic group (64%).
Discussion: Although not statistically significant, related biomarkers such as plasma zinc levels and CD4 levels were lower in the hyperglycemic group. This may be due to the role zincplays in the immune system. Due to the fact that there was a higher percentage of plasma zinc deficiency in the hyperglycemic group (69%) compared to the normoglycemic group (64%), it is important to monitor and manage blood glucose levels to minimize complications. Our findings along with previous findings suggest that zinc supplementation may benefit hyperglycemic PLWH.