alexa Lower Starting Dose of Sorafenib for Thyroid Cancer : A Case Report and Literature Review
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Case Report

Lower Starting Dose of Sorafenib for Thyroid Cancer : A Case Report and Literature Review

Eun Mi Lee, Ju Won Lee, Jun Yeob Lee and Bu Kyung Kim*
Department of Internal Medicine, Division of Endocrinology and Metabolism, Kosin University College of Medicine, Kosin University Gospel Hospital, Busan, Korea
Corresponding Author : Kim KB
Department of Internal Medicine
Division of Endocrinology and Metabolism
Kosin University College of Medicine
Kosin University Gospel Hospital, Busan, Korea
Tel: 82-51-990-6532
E-mail: [email protected]
Received: September 25, 2015; Accepted: October 14, 2015; Published: October 19, 2015
Citation: Kim Bk, Lee Jy, Lee Jw, Lee EM (2015) Lower Starting Dose of Sorafenib for Thyroid Cancer : A Case Report and Literature Review. Thyroid Disorders Ther 4:196. doi:10.4172/2167-7948.1000196
Copyright: © 2015 Lee ME, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Since the FDA approved sorafenib use for thyroid cancer, administration of this medicine to thyroid-cancer patients had steadily increased. However, an appropriate starting dose for this treatment has not been established, which is problematic because the sorafenib discontinuation rate due to toxicity is higher among thyroid cancer patients than among patients with other solid tumors. We recently treated a papillary thyroid cancer patient who experienced a dramatic improvement after being treated with a 400-mg starting dose of sorafenib. Herein, we describe this case and discuss its implications for an appropriate sorafenib starting dose for thyroid cancer.

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