Lung Stem/Progenitor Cells: Regulatory Mechanisms of Behavior, Development and RegenerationAhmed HK El-Hashash*
Developmental Biology, University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
- Corresponding Author:
- Ahmed El-Hashash
Assistant Professor, Developmental Biology
Regenerative Medicine and Stem Cell Program
Saban Research Institute, Children’s Hospital Los Angeles
4661 Sunset Boulevard MS 35, Los Angeles, California 90027, USA
Tel: 323-361-2764, 323-361-2258
E-mail: [email protected]
Received Date: June 17, 2013; Accepted Date: June 20, 2013; Published Date: June 22, 2013
Citation: El-Hashash AHK (2013) Lung Stem/Progenitor Cells: Regulatory Mechanisms of Behavior, Development and Regeneration. Anatom Physiol 3:119. doi: 10.4172/2161-0940.1000119
Copyright: © 2013 El-Hashash AHK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
New insights have been added to identification and characterization of stem and progenitor cells in the lung over the last few years. The exploration of endogenous lung stem and progenitor cells holds promise for advancing our understanding of the biology of lung repair and regeneration mechanisms after injury. This will also help in the future use of stem cell therapy for the development of regenerative medicine approaches for the treatment of different lung diseases. In this concise review, we describe the main types of lung stem/progenitor cell populations as well as summarize recent research progress and accumulated information regarding the behavior, development and function of stem/progenitor cells in the lung, and factors controlling their repair/regeneration after injury as well as molecular mechanisms regulating lung stem/progenitor cell behavior during development.