Lymphangiogenesis and its Role in Physiologic Wound Healing and the Pathogenesis of Pulmonary FibrosisSarah MH and Abigail L*
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver, University of Colorado, Aurora, USA
- *Corresponding Author:
- Abigail L
Division of Pulmonary Sciences and
Critical Care Medicine
University of Colorado at Denver
University of Colorado
E-mail: [email protected]
Received Date: June 25, 2015; Accepted Date: November 23, 2015; Published Date: December 10, 2015
Citation: Sarah MH, Abigail L (2015) Lymphangiogenesis and its Role in Physiologic Wound Healing and the Pathogenesis of Pulmonary Fibrosis. J Vasc Med Surg 3:236. doi:10.4172/2329-6925.1000236
Copyright: © 2015 Sarah MH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Wound healing and repair is a physiologic process that occurs following tissue injury often resulting in a controlled scar formation. However, in certain disease states, the intrinsic mechanisms that signal the completion of repair are defunct leading to continued repair, resulting in excessive fibrosis. Numerous segments of the wound healing process are known to be deregulated in idiopathic pulmonary fibrosis (IPF) including increased myofibroblast activation, excessive extracellular matrix (ECM) deposition, and decreased injury resolution. In this review we will focus on one part of the wound healing process, lymphangiogenesis and lymphatic remodeling, and its potential role in the pathogenesis of pulmonary fibrosis.