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Lymphomatoid Papulosis Misdiagnosed as Anaplastic Lymphoma | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Case Report

Lymphomatoid Papulosis Misdiagnosed as Anaplastic Lymphoma

Caius Solovan1,2 and Flavia Baderca3,4*

1Dermatology, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania

2Department of Dermatology, Emergency City Hospital, Timișoara, Romania

3Department of Microscopic Morphology, “Victor Babeş” University of Medicine and Pharmacy, Timișoara, Romania

4Discipline of Pharmaceutics, School of Pharmacy, University of the Western Cape, Bellville 7535, South Africa

*Corresponding Author:
Flavia Baderca
Associate Professor
Department of Microscopic Morphology
“Victor Babeş” University of Medicine and Pharmacy
2 Eftimie Murgu Square, 300077 Timişoara, Romania
Tel: +40733-106-101
E-mail: [email protected]

Received Date: February 15, 2016; Accepted Date: April 15, 2016; Published Date: April 25, 2016

Citation: Solovan C, Baderca F (2016) Lymphomatoid Papulosis Misdiagnosed as Anaplastic Lymphoma. J Cytol Histol 7: 415. doi: 10.4172/2157-7099.1000415

Copyright: © 2016 Solovan C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Lymphomatoid papulosis is a very rare skin disorder, defined as a chronic, recurrent, self-healing papulonodular or papulonecrotic skin eruption with suggestive histopathological features of a cutaneous lymphoma. We report a case of a 47-year-old male with an 8 years history of recurrent papulonodular lesions, some ulcerated, located on the face, trunk and extremities. The patient has been diagnosed primary with staphylococcal infection based on the clinical features and then, after a skin biopsy with anaplastic large cell lymphoma with CD30 positive cells and treated with CHOP. When he stopped the therapy, the lesions reappeared. A second skin biopsy was performed. Histological examination revealed an infiltrate of dyscohesive atypical lymphoid cells at the dermal-epidermal junction extending in the deep dermis. These atypical lymphoid cells varied in size and had pale abundant cytoplasm. Mitoses including atypical forms were prominent. Small mature appearing lymphocytes admixed with neutrophils and eosinophils were scattered throughout the tumor. Immunohistochemical studies demonstrated that the atypical lymphoid cells expressed CD30, Bcl-2 and Ki-67 (90%). Considering also the clinicopathological correlation, the morphological and immunohistochemical stains were suggestive for the diagnosis of lymphomatoid papulosis type A. Keywords: Lymphomatoid papulosis

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