alexa Magnesium Metabolism, Vitamin D and Interleukins in Cardiovascular Disease
ISSN: 2153-0769

Metabolomics:Open Access
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Research Article

Magnesium Metabolism, Vitamin D and Interleukins in Cardiovascular Disease

Kisters K1*, Gremmler B2, Gröber U3 and Tokmak F1*

1Med Clinic I, St. Anna Hospital, Hospitalstr. 19, Herne 44649, Germany

2Department of Cardiology, Bottrop, Germany

3Academy for Micronutrients, Essen, Germany

*Corresponding Author:
Kisters K
Med Clinic I, St. Anna Hospital
Hospitalstr. 19, Herne 44649, Germany
Tel: 4923259862100
E-mail: [email protected]

Received Date: May 18, 2016; Accepted Date: June 16, 2016; Published Date: June 20, 2016

Citation: Kisters K, Gremmler B, Gröber U, Tokmak F (2016) Magnesium Metabolism, Vitamin D and Interleukins in Cardiovascular Disease. Metabolomics 6:177. doi:10.4172/2153-0769.1000177

Copyright: © 2016 Kisters K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A magnesium deficiency is known to be involved in the pathogenesis of cardiovascular diseases. In patients with essential hypertension intima media thickness is increased in about 70% (ELSA Study). In our study, we investigated 21 patients (10 female, 11 male, average age 56.3 ± 6.6 years) with untreated essential hypertension (grades I and II according to WHO guidelines). All patients had a hypomagnesiaemia in serum (1.57 ± 0.11 mg%). In all patients we found a significant increase in intima media thickness of arteria carotis communis (0.97 ± 0.08 mm) (r=-0.869, p<0.0001). The results show that a magnesium deficiency in patients with essential hypertension may be of special pathogenetic importance. In addition, the role of magnesium deficiency in the development of arteriosclerosis has to be discussed. Furthermore, we demonstrated a connection between magnesium deficiency and an increased intima media thickness. In this context, calcium antagonist therapy or magnesium supplementation may be of advantage when treating intima media thickness in hypertension. In addition in essential hypertensives with diabetes mellitus type IIb showing lowered magnesium (1.72 ± 0.08 mg/ dl) and vitamin D (9.55 ± 4.74 ng/ml) levels interleukine 6 concentrations were 8.57 ± 4.14 pg/ml (p<0.01 vs. controls) being a risk factor for metabolic disorder, e. g. arteriosclerosis.


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