alexa Magnetic Control of Enzymatic Phosphorylation
ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
Open Access

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Review Article

Magnetic Control of Enzymatic Phosphorylation

Anatoly L. Buchachenko1,2* and Dmitry A. Kuznetsov1,3
1Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432 Chernogolovka, Russian Federation
3Russian National Research Medical University, 117997 Moscow, Russian Federation
Corresponding Author : Anatoly L. Buchachenko
Institute of Chemical Physics
Russian Academy of Sciences
119991 Moscow, Russian Federation
Tel: 7495-939-7128
E-mail: [email protected]
Received March 29, 2014; Accepted May 21, 2014; Published May 23, 2014
Citation: Buchachenko AL, Kuznetsov DA (2014) Magnetic Control of Enzymatic Phosphorylation. J Phys Chem Biophys 4:142. doi:10.4172/2161-0398.1000142
Copyright: © 2014 Buchachenko AL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Ion-radical mechanism of the phosphorylation in the three processes of paramount importance – enzymatic ATP synthesis, DNA replication, and enzymatic phosphorylation of proteins, which are three cornerstones of the life chemistry, was discovered by using pure isotope forms of metal (magnesium, zinc, calcium) ions catalyzing enzymatic phosphorylation. It is convincingly proved by magnetic isotope and magnetic field effects on these processes. Ionradical mechanism is inevitable because on the pathway of compression of reactants in any molecular machine (enzyme) electron transfer occurs which precedes generally accepted nucleophilic reaction. Ion-radical mechanism being controlled by magnetic interactions is switched on when at least two metal ions enter in catalytic site: the first one is tightly bound with phosphate group, the second one is ‘free’, and not bound with phosphate groups; it acts as an electron acceptor, it is a main actor of the ion-radical mechanism. This mechanism may be also switched off by presence of Fe ions. Ion-radical mechanism manifests itself in the ATP synthesis in isolated mitochondria and in the whole living organisms as well in the widely used polymerase chain reaction of the DNA replication. The mechanism can be used to stimulate ATP synthesis and eliminate ATP deficiency at cardiac diseases, to control cell proliferation, to kill cancer cells, and control trans-cranial magnetic stimulation against cognitive deceases.

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