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Magnetic Resonance Imaging as a Tool for the Study of Mouse Models of Autism | OMICS International | Abstract
ISSN: 2165-7890

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Review Article

Magnetic Resonance Imaging as a Tool for the Study of Mouse Models of Autism

Jacob Ellegood1*, R. Mark Henkelman1,2 and Jason P. Lerch1,2

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada

2Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

*Corresponding Author:
Jacob Ellegood
Mouse Imaging Centre
Hospital for Sick Children
25 Orde Street, Toronto
Ontario, M5T 3H7, Canada
E-mail: [email protected]

Received date: August 30, 2012; Accepted date: November 16, 2012; Published date: November 19, 2012

Citation: Ellegood J, Henkelman RM, Lerch JP (2012) Magnetic Resonance Imaging as a Tool for the Study of Mouse Models of Autism. Autism S1:008. doi:10.4172/2165-7890.S1-008

Copyright: © 2012 Ellegood J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Autism is a heterogeneous disorder, in both its behaviour and genetics. This heterogeneity has led to inconsistencies in the neuroanatomical findings in human autistic patients. The benefit of a model system, such as the mouse, is that there could be a decrease in the heterogeneity of the genetics and standardization of the environment could be done, in order to determine a specific anatomical phenotype, which is representative of a specific genotype. Magnetic Resonance Imaging (MRI) has been used quite extensively to examine morphological changes in the mouse brain; however, examining volume and tissue microstructure changes in mouse models of autism with MRI, is just in its infancy. This review will discuss the current research on anatomical phenotyping in mouse models of autism.

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