Main Pathways of Proteome Simplification in Alphaherpesviruses Under the Influence of the Strong Mutational GC-pressure
Vladislav V. Khrustalev* and Eugene V. Barkovsky
Department of General Chemistry, Belarussian State Medical University, Belarus, Minsk, Dzerzinskogo, 83
- *Corresponding Author:
- Vladislav V. Khrustalev,
Tel : 80292845957,
E-mail : [email protected]
Received Date: January 14, 2009; Accepted Date: February 09, 2009; Published Date: February 20, 2009
Citation: Khrustalev VV, Barkovsky EV (2009) Main Pathways of Proteome Simplification in Alphaherpesviruses Under the Influence of the Strong Mutational GC-pressure. J Proteomics Bioinform 2:088-096.doi:10.4172/jpb.1000065
Copyright: © 2009 Khrustalev VV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The simplification of amino acid content distribution under the influence of the strong mutational pressure takes place in simplex and varicello viruses proteins coded by genes with GC-content higher than 60%. We proved this statement by the way of in-silico calculation of Shannon’s entropy of amino acid content distribution in all proteins from ten completely sequenced simplex and varicello viruses. Entropy of amino acid content distribution decreases because of the growth of GARP (glycine, alanine, arginine and proline) usage due to the decrease not only in FYMINK (phenylalanine, tyrosine, methionine, isoleucine, asparagine and lysine) but also in other amino acids (coded by codons with average GC-content) usages. Threonine, serine, glutamine and cysteine are frequently substituted to GARP in proteins coded by genes with G+C higher than 60% (threonine and serine are substituted mostly to alanine while glutamine and histidine are substituted mostly to arginine). Cysteine, valine and leucine are frequently substituted to GARP only in proteins coded by genes with G+C higher than 80%, probably because of the higher radicalism of these substitutions. Levels of tryptophan, glutamic and aspartic acids do not decrease under the influence of GC-pressure even in proteins coded by genes with G+C higher than 80%.