alexa Making of a Unique Birth Control Vaccine against hCG with Additional Potential of Therapy of Advanced Stage Cancers and Prevention of Obesity and Insulin Resistance | Abstract
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Review Article

Making of a Unique Birth Control Vaccine against hCG with Additional Potential of Therapy of Advanced Stage Cancers and Prevention of Obesity and Insulin Resistance

Talwar G.P1, Susana B. Rulli2, Hemant Vyas3, Shilpi Purswani1 , Rafi Shiraz Kabeer1, Prem Chopra4, Priyanka Singh1, Nishu Atrey1, Kripa Nand1 and Jagdish C. Gupta1

1Talwar Research Foundation, New Delhi, India

2Instituto de Biologia y Medicina Experimental CONICET Bueno Aires Argentina, Argentina

3Harvard Medical School Boston, USA

4Sir Ganga Ram Hospital, New Delhi, India

*Corresponding Author:
Talwar G.P
Talwar Research Foundation
E-8, Neb Valley Neb Sarai
New Delhi 110068, India
Tel: 011-29531028
E-mail: [email protected]

Received date: February 19, 2014; Accepted date: March 27, 2014; Published date: March 28, 2014

Citation: Talwar GP, Rulli SB, Vyas H, Purswani S, Kabeer RS, et al. (2014) Making of a Unique Birth Control Vaccine against hCG with Additional Potential of Therapy of Advanced Stage Cancers and Prevention of Obesity and Insulin Resistance. J Cell Sci Ther 5:159. doi: 10.4172/2157-7013.1000159

Copyright: © 2014 Talwar GP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Reviewed is the work which led to the development of a unique vaccine that prevents pregnancy in sexually active women without impairment of ovulation and block of their making normally their sex steroid hormones. Being given that hCG is not expressed by non-pregnant females, immunization with the vaccine is devoid of any crossreaction with any tissue of the body. It is totally reversible and women regained fertility on decline of antibodies. A recombinant vaccine has been developed which is highly immunogenic in mice. It is undergoing extensive toxicology under GLP conditions in rodents and a primate species, the marmosets, before resumption of clinical trials. Ectopic expression of hCG or its subunits takes place in a variety of cancers, particularly at advanced stage with adverse survival and poor prognosis. Anti-hCG antibodies exercise therapeutic action against such cancers as indicated by in vitro culture and in vivo studies in nude mice. Transgenic hCG β mice put on weight and manifest insulin resistance. Immunization of these mice with the recombinant hCG β-LTB vaccine prevents obesity and insulin resistance.

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