alexa Malignancy after Heart Transplantation: A Systematic Review of the Incidence and Risk Factors Compared with Other Solid Organ Transplants | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Case Report

Malignancy after Heart Transplantation: A Systematic Review of the Incidence and Risk Factors Compared with Other Solid Organ Transplants

Brian Chiu*, Consolato Sergi
Department of Laboratory Medicine and Pathology, University of Alberta, AB, Canada
Corresponding Author : Brian Chiu
Department of Laboratory Medicine and Pathology
University of Alberta Hospital
8440–112 Street, Edmonton, AB, Canada
Tel: 780-407-6959
Fax: 780-407-3009
E-mail: [email protected]
Received April 10, 2013; Accepted May 17, 2013; Published May 20, 2013
Citation: Chiu B, Sergi C (2013) Malignancy after Heart Transplantation: A Systematic Review of the Incidence and Risk Factors Compared with Other Solid Organ Transplants. J Clin Exp Cardiolog S9:005. doi: 10.4172/2155-9880.S9-005
Copyright: © 2013 Chiu B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The continuing improvements in heart transplant (HT) outcomes have increased the risk of developing complications, such as post-transplant malignancy (PTM). Our aims are to focus on the incidence and risk factors in PTM in heart transplant recipients and compare with other solid organ transplantations (SOT). In 20 publications analyzed, the incidence of PTM in individuals undergoing SOT ranges from 4.1% to 16.3%, representing a 2 to 4-fold overall increased risk of cancer over the general population. It seems that the incidence of cancer risk is probably higher in HT than SOT recipients. Cutaneous carcinomas, post-transplant lymphoproliferative disorders (PTLD), carcinomas of lung and liver represent the four most common malignancies in this specific post-transplant population. It is also evident that the risk factors in developing PTM in HT recipients include immunosuppressive therapy, viral infection, older age, tobacco smoking, and unprotected sun-exposure. Transplant physicians should probably increase the threshold of attention for cancer risk surveillance in addition to anti-rejection therapy for graft survivals.

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