Malignant Granular Cell Tumor with an Unusually Long Clinical Course: An Autopsy Case with Review of LiteratureTsuyoshi Saito1*, Hiroyuki Mitomi1, Tomoaki Torigoe2, Tatsuya Takagi2, Yoshiyuki Suehara2, Taketo Okubo1,2, Kazuo Kaneko2 and Takashi Yao1
- *Corresponding Author:
- Tsuyoshi Saito, M.D, Ph.D
Department of Human Pathology
Juntendo University School of Medicine
Hongo 2-1-1, Bunkyo-ku
Tokyo, Japan 113-8421
E-mail: [email protected]
Received date: July 16, 2012; Accepted date: August 14, 2012; Published date: August 16, 2012
Citation: Saito T, Mitomi H, Torigoe T, Takagi T, Suehara Y, et al. (2012) Malignant Granular Cell Tumor with an Unusually Long Clinical Course: An Autopsy Case with Review of Literature. J Cancer Sci Ther 4:260-263. doi:10.4172/1948-5956.1000152
Copyright: © 2012 Saito T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We present an autopsy case of malignant granular cell tumor with an unusual clinical course. The patient had noticed a tumor on his neck 13 years prior to hospital admission. The tumor was resected and diagnosed as a malignant granular cell tumor fulfilling all 6 criteria proposed by Fanburg-Smith et al. Histologically, the tumor consisted of an extensive malignant area with adjacent small areas of benign granular cell tumor at the periphery. The patient received systemic chemotherapy and radiation, but little effect was noted. The tumor recurred 1.5 months after resection and grew rapidly. At autopsy, the tumor had metastasized to various organs, and carcinomatous lymphangiosis was present. Immunohistochemistry revealed diffuse S-100 protein expression but no expression of c-kit or EGFR and Ki-67 index in the malignant area was approximately 40%. This case report demonstrates the potential of benign granular cell tumors for malignant transformation.