alexa Maternal Gut Microbes Control Offspring Sex and Survival | OMICS International| Abstract

ISSN: 2329-8901

Journal of Probiotics & Health

  • Research Article   
  • J Prob Health,
  • DOI: 10.4172/2329-8901.1000120

Maternal Gut Microbes Control Offspring Sex and Survival

Yassin M Ibrahim1#, Sean M Kearney1,2#, Tatiana Levkovich1, Alex Springer1,2, Sheyla Mirabal1, Theofilos Poutahidis1,3, Bernard J Varian1, Jessica R Lakritz1, Eric J Alm2,4 and Susan E Erdman1*
1Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
2Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
3Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
4Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
#Contributed equally to this work
*Corresponding Author : Susan E Erdman, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, Tel: 617-252-1804, Fax: 508-435-3329, Email: [email protected]

Received Date: Aug 08, 2014 / Accepted Date: Sep 16, 2014 / Published Date: Sep 23, 2014

Abstract

Sex outcome and maternal investment in progeny are important predictors of reproductive success. While environmental factors appear to influence these processes, there is little evidence to date of a direct role for gut commensals. Here we show that the reproductive outcomes (sex and survival) of mouse litters depend on signals conveyed through the microbiome. We discover that transient treatment of mouse mothers with specific microorganisms increases the absolute survival of offspring and skews offspring sex ratios via an endocrine-dependent mechanism requiring the neurophysiological hormone oxytocin. The implication of maternal oxytocin levels suggests that commensal microbes may have a broad role in modulating host endocrine and neurological pathways.

Keywords: Lactobacillus reuteri; Oxytocin; Sex ratio

Citation: Ibrahim YM, Kearney SM, Levkovich T, Springer A, Mirabal S, et al. (2014) Maternal Gut Microbes Control Offspring Sex and Survival. J Prob Health 2: 120. Doi: 10.4172/2329-8901.1000120

Copyright: ©2014 Ibrahim YM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment
Share This Article
Recommended Conferences
Viewmore
Article Usage
  • Total views: 12166
  • [From(publication date): 11-2014 - Apr 20, 2018]
  • Breakdown by view type
  • HTML page views: 8372
  • PDF downloads: 3794