alexa Maternal Obesity and Placental Oxidative Stress in the First Trimester
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Maternal Obesity and Placental Oxidative Stress in the First Trimester

Mark C. Alanis1*, Elizabeth M. Steadman1, Yefim Manevich2, Danyelle M. Townsend3 and Laura M. Goetzl1
1Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 634, Charleston, South Carolina 29425, USA
2Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
3Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, 280 Calhoun Street, Charleston, South Carolina 29425, USA
Corresponding Author : Mark C. Alanis
Department of Obstetrics and Gynecology
Medical University of South Carolina, 96 Jonathan Lucas Street
CSB 634, Charleston, SC 29425, USA
Tel: (843) 792-1241
Fax: (843) 792-0533
E-mail: [email protected]
Received June 20, 2012; Accepted August 06, 2012; Published August 12, 2012
Citation: Alanis MC, Steadman EM, Manevich Y, Townsend DM, Goetzl LM (2012) Maternal Obesity and Placental Oxidative Stress in the First Trimester. J Obes Wt Loss Ther 2:143. doi:10.4172/2165-7904.1000143
Copyright: © 2012 Alanis MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: Maternal obesity is associated with adverse pregnancy outcomes affected by placental dysfunction. We sought to compare levels of placental oxidative stress between obese and lean women in the first trimester.
 
Study Design: Obese and lean women matched 1:1 for baseline variables and gestational age were enrolled between 8 and 13 weeks of gestation at the time of voluntary surgical abortion. The global cellular redox status was determined by measuring the total protein thiol content in placental homogenates and serum (ThioGlo-1).
 
Results: There were no differences in baseline variables between obese (n=22, median BMI 35.0) and lean controls (n=22, median BMI 22.0). The median level of placental oxidative stress was 31% greater in the obese group compared to the lean group (141.1 [117-156] vs. 203.7 [189-234] counts/sec/μg protein, respectively; p <0.001). A similar but statistically insignificant difference was noted in the serum (12.2 [9-15] vs. 13.6 [12-23] counts/sec/μcg protein; p=0.09).
 
Conclusion: Maternal obesity is associated with placental oxidative stress in the first trimester. Oxidative stress in the first trimester may reflect or contribute to impaired placentation and placental dysfunction in obese women.

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