alexa Mathematical Models of the Pharmacokinetic Behavior of
ISSN: 2329-6631

Journal of Developing Drugs
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Research Article

Mathematical Models of the Pharmacokinetic Behavior of Digoxin in Five Healthy Subjects following Rapid Intravenous Injection of 1 mg of Digoxin

Mária Durišová*

Department of Pharmacology of Inflammation, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Slovak Republic

*Corresponding Author:
Mária Durišová
Department of Pharmacology of Inflammation
Institute of Experimental Pharmacology and Toxicology
Slovak Academy of Sciences
Dúbravská cesta 9, 84104 Bratislava
Slovak Republic
Tel: +421-2-54775928
E-mail: [email protected]

Received date: October 20, 2015; Accepted date: November 04, 2015; Published date November 24, 2015

Citation: Durišová M (2015) Mathematical Models of the Pharmacokinetic Behavior of Digoxin in Five Healthy Subjects following Rapid Intravenous Injection of 1 mg of Digoxin. J Develop Drugs 4:143. doi:10.4172/2329-6631.1000143

Copyright: © 2015 Durišová M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: The main objective of the current study was to present a further example which showed that a nontraditional mathematical modeling method can be advantageously used for the development of mathematical models in pharmacokinetics. An additional objective was to motivate researchers working in the field of pharmacokinetics to use a modeling method based on the theory of dynamic systems in their research work. Method: The current study is a companion piece of the earlier study by Kramer et al. Therefore the data published in the study cited here were used. As stated above, an advanced modeling method based on the theory of dynamic systems was employed. Conclusions: All mathematical models developed, successfully described the data of all volunteers investigated in the previous study by Kramer et al. and in the current study. The modeling method used in the current study is universal, comprehensive, and flexible. Therefore, it can be used to developed mathematical models not only in pharmacokinetics but also in several other scientific and practical fields.


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