Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in AsthmaNeveen Abd El-Moneum Hassan1, Alia? Abd-Rabou Mohamed-Hussein2*, Ebtssam F. Mohammed1, Omnia Abd El-Moneum Mohamed1, Hanan O Mohamed1and Manal Mohamed Tammam Mahmoud1
- *Corresponding Author:
- Alia? AR Mohamed-Hussein
MD, Professor of Pulmonology
Faculty of Medicine
Assiut University, Egypt
E-mail: [email protected]
Received date: April 18, 2015; Accepted date: June 01, 2015; Published date: June 04, 2015
Citation: El-Moneum Hassan NA, Mohamed-Hussein AAT, Mohammed EF, El- Moneum Mohamed OA, Mohamed HO, et al. (2015) Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in Asthma. J Pulm Respir Med 5:266. doi: 10.4172/2161-105X.1000266
Copyright: © 2015 Abd El-Moneum Hassan NA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Rationale: Airway remodelling is clinically defined as persistent airflow obstruction despite aggressive antiinflammatory therapies. Assessment of airway remodelling by analysis of serum markers has been developed as minimally invasive procedures.
Aim of the work: Evaluate the usefulness of estimation of serum MMP-9, TIMP-1 and their ratio, as non-invasive markers of airway remodelling in asthmatics.
Patients and methods: The study included 68 asthmatics and 20 controls. Patients were classified according to levels of asthma control, severity and disease duration. Serum samples were taken to estimate levels of MMP-9, TIMP-1 and their ratio.
Results: Serum MMP-9, TIMP-1, and MMP-9/TIMP-1 were significantly higher in asthmatics than controls, in uncontrolled vs. controlled asthma (P<0.001). Also they were significantly higher in severe and moderate asthma than in mild asthma (P<0.000), and in patients with disease duration >5 years vs. <5 years (P?0.001). There was significant positive correlation between studied parameters (p<0.000) and significant negative correlation between the biomarkers and FEV1 (p<0.001).
Conclusion: Serum MMP-9, TIMP-1, and MMP-9/TIMP-1 could be considered as non-invasive markers of airway remodelling that can bypass biopsy sampling. Serum sample is easily handled and not subjected to technical error as sputum or BAL fluid.