alexa MB1533 is a Defensin-Like Antimicrobial Peptide from the Intracellular Meristem Endophyte of Scots Pine Methylobacterium extorquens DSM13060
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
Open Access

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Research Article

MB1533 is a Defensin-Like Antimicrobial Peptide from the Intracellular Meristem Endophyte of Scots Pine Methylobacterium extorquens DSM13060

Tejesvi M1*, Birgitte A2, Nikolinka A3, Karoline B2, Janne K1, Hans-Henrik K2, Alex T3 and Anna P1

1Faculty of Science, Genetics and Physiology, University of Oulu, Finland

2Novozymes AS, DK-2880 Bagsvaerd, Denmark

3Department of Biochemistry, University of Trieste, Trieste, Italy

*Corresponding Author:
Tejesvi M
Faculty of Science
Genetics and Physiology
University of Oulu, Finland
Tel: +358503501136
E-mail: [email protected]

Received Date: November 25, 2015; Accepted Date: December 06, 2015; Published Date: December 13, 2015

Citation: Tejesvi MV, Andersen B, Antcheva N, Brinch KS, Koskimäki JJ, et al. (2016) MB1533 is a Defensin-Like Antimicrobial Peptide from the Intracellular Meristem Endophyte of Scots Pine Methylobacterium extorquens DSM13060. J Microb Biochem Technol 8: 001-005. doi:10.4172/1948-5948.1000252

Copyright: © 2015 Tejesvi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Endophytes induce plant growth and protect host plants against abiotic and biotic stresses, such phytopathogenic bacteria and fungi. Here we explored the genome of plant growth-promoting, intracellular endophyte Methylobacterium extorquens DSM13060, isolated from bud meristems of Pinus sylvestris L., for antimicrobial peptides. A defensinlike antimicrobial peptide MB1533 was identified using computational and prediction models from the genome sequence. MB1533 was produced in Escherichia coli with a molecular weight of 6160.26 Da. The antimicrobial activity was tested against several strains of bacteria and yeasts, and the peptide had activity against the grampositive Staphylococcus aureus and Bacillus subtilis at 128 μg/ml. The potency of the peptide can be improved further by rational-design-techniques. MB1533 is the first defensin-like peptide identified from Methylobacterium genus and from bacterial endophytes, in general.


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