alexa MD Simulation Studies of Fumarase Reveal Thermo Dynamical Stability | OMICS International| Abstract

ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics

  • Short Communication   
  • J Phys Chem Biophys 2014, Vol 6(1): 206
  • DOI: 10.4172/2161-0398.1000206

MD Simulation Studies of Fumarase Reveal Thermo Dynamical Stability

Salam Pradeep Singh1*, Chitta Ranjan Deb2, Lakhmi Nandan Kakati3 and Bolin Kumar Konwar4
1Bioinformatics Infrastructure Facility, Nagaland University, Lumami 798627, Nagaland, India
2Department of Botany, Nagaland University, Lumami 798627, Nagaland, India
3Department of Zoology, Nagaland University, Lumami 798627, Nagaland, India
4Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India
*Corresponding Author : Salam Pradeep Singh, Bioinformatics Infrastructure Facility, Nagaland University, Lumami-798 627, Nagaland, India, Tel: +918486268935, Email: [email protected]om

Received Date: Feb 15, 2016 / Accepted Date: Feb 24, 2016 / Published Date: Feb 29, 2016

Abstract

Fumarase enzyme is known to catalyse the stereo specific inter conversion of fumarate to L-malate which is a part of the Krebs cycle. Despite the biological significance and importance of this enzyme, the reaction mechanism of fumarase is not completely understood or known. In this context an experiment on molecular dynamics simulation was carried out for at least 10 nanoseconds molecular dynamics simulation run using Nano Scale Molecular Dynamics program implemented in Discovery Studio 4.0. The trajectory analysis of various energy parameters revealed the thermo dynamical stability of the enzyme. The present findings may aid in understanding the biological significance of this enzyme.

Keywords: Fumarase; Molecular dynamics; Krebs cycle

Citation: Singh SP, Deb CR, Kakati LN, Konwar BK (2016) MD Simulation Studies of Fumarase Reveal Thermo Dynamical Stability. J Phys Chem Biophys 6: 206. Doi: 10.4172/2161-0398.1000206

Copyright: © 2016 Singh SP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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