alexa MD Simulation Studies of Fumarase Reveal Thermo Dynamic
ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Short Communication

MD Simulation Studies of Fumarase Reveal Thermo Dynamical Stability

Salam Pradeep Singh1*, Chitta Ranjan Deb2, Lakhmi Nandan Kakati3 and Bolin Kumar Konwar4
1Bioinformatics Infrastructure Facility, Nagaland University, Lumami 798627, Nagaland, India
2Department of Botany, Nagaland University, Lumami 798627, Nagaland, India
3Department of Zoology, Nagaland University, Lumami 798627, Nagaland, India
4Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India
Corresponding Author : Salam Pradeep Singh
Bioinformatics Infrastructure Facility
Nagaland University, Lumami-798 627
Nagaland, India
Tel: +918486268935
E-mail: [email protected]
Received: February 15, 2016 Accepted: February 24, 2016 Published: February 29, 2016
Citation: Singh SP, Deb CR, Kakati LN, Konwar BK (2016) MD Simulation Studies of Fumarase Reveal Thermo Dynamical Stability. J Phys Chem Biophys 6:206. doi:10.4172/2161-0398.1000206
Copyright: © 2016 Singh SP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Fumarase enzyme is known to catalyse the stereo specific inter conversion of fumarate to L-malate which is a part of the Krebs cycle. Despite the biological significance and importance of this enzyme, the reaction mechanism of fumarase is not completely understood or known. In this context an experiment on molecular dynamics simulation was carried out for at least 10 nanoseconds molecular dynamics simulation run using Nano Scale Molecular Dynamics program implemented in Discovery Studio 4.0. The trajectory analysis of various energy parameters revealed the thermo dynamical stability of the enzyme. The present findings may aid in understanding the biological significance of this enzyme.

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