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ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Measles Virus: Association with Cancer

Samuel Ariad1*, Irena Lazarev1 and Daniel Benharroch2
1Department of Oncology, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
2Department of Pathology, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
Corresponding Author : Samuel Ariad
Department of Oncology, Soroka Medical Center
Beer Sheva, P.O.Box 151, Israel 84101
Tel : 972-8-6400537
Fax: 972-8- 6232336
E-mail: [email protected]
Received: November 15, 2011; Accepted: December 07, 2011; Published: December 19, 2011
Citation: Ariad S, Lazarev I, Benharroch D (2011) Measles Virus: Association with Cancer. J Clin Cell Immunol S5:002. doi:10.4172/2155-9899.S5-002
Copyright: © 2011 Ariad S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Measles virus (MV) is a member of the paramyxovirus family of enveloped RNA viruses and one of the most infectious viral pathogens identified. Despite initial optimism that vaccination programs would eventually eradicate measles, reduced vaccination coverage against measles continues to result in outbreaks of measles. Mild or asymptomatic measles infections are common among measles-immune persons exposed to measles cases and may be the most common manifestation of measles during outbreaks in highly immune populations. Persistent, asymptomatic MV infections commonly persist in apparently healthy individuals. MV has been detected in several malignancies, including lung, breast, and endometrial cancers, as well as Hodgkin’s lymphoma. The presence of MV in these tumors was associated with distinct clinico-pathological characteristics: in lung cancer, older ages of patients and over expression of Pirh2, and in breast cancer, age less than 50 years, lower histological grade, and over expression of p53. Nectin-4 is the MV receptor in epithelial cells and is highly expressed in certain epithelial tumors. MV-associated tumorigenesis may be linked to the effect of MV-phosphoprotein on Pirh2, an E3 ubiquitin ligase of p53. By way of MV interaction with Nectin-4 and Pirh2, persistent MV infection may co-act with other factors in transforming cells to become malignant.

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