alexa Measurement of Indoleamine 2, 3 Dioxygenase Activity in Colorectal Cancer: A Controlled Group Study
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Measurement of Indoleamine 2, 3 Dioxygenase Activity in Colorectal Cancer: A Controlled Group Study

Daniel Eyraud1-3, Benjamin Granger4, Noel Zahr5, Frédéric Charlotte6, Armelle Bardier6, Gaëlle Gottrand3, Audrey Perez-Lascar3, Mehdi Karoui2, Louis Lemoine1, Jean Christophe Vaillant2, David Klatzmann3, Laurent Hannoun2 and Pierre Coriat1
1Department of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
2Department of Digestive and HPB Surgery, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
3Department of Biotherapies CNRS 7211 INSERM 959, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
4Department of statistics, Clinical Research Unit, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
5Department of Clinical Pharmacology, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
6Department of histology and UIMAP, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière University Hospital, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
Corresponding Author : Daniel Eyraud
Assistance Publique-Hôpitaux de Paris (AP-HP)
Pitié-Salpêtrière University Hospital, Department of Anesthesiology
and Reanimation, 43-87 Boulevard de l’Hôpital, 75013 Paris, France
Tel: 00 33 1 42 17 58 65
Fax: 00 33 1 42 17 56 13
E-mail: [email protected]
Received: September 21, 2015 Accepted: November 28, 2015 Published: December 08, 2015
Citation: Eyraud D, Granger B, Zahr N, Charlotte F, Bardier A, et al. (2015) Measurement of Indoleamine 2, 3 Dioxygenase Activity in Colorectal Cancer: A Controlled Group Study. J Clin Cell Immunol 6:374. doi:10.4172/2155-9899.1000374
Copyright: © 2015 Eyraud D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme that converts tryptophan (Trp) to kynurenine (Kyn), suppresses antitumor immune responses via depletion of Trp and accumulation of Kyn. We hypothesized that, in colorectal cancer (CRC), IDO activity may serve as a biomarker and thus we compared the IDO activity between patients with CRC and those without CRC. We further assessed the effect of surgical treatment of CRC on IDO activity.

Methods: Serum concentrations of Trp and Kyn were measured by high performance liquid chromatography in the sera of 68 patients with CRC (CRC group) and 38 without CRC (Control group) prior surgery (D0) and 7 days after surgery (D7). The IDO activity was estimated by the serum Kyn-to-Trp ratio (Kyn/Trp ratio).

Results: At Day 0, serum Kyn concentration was higher in the CRC group than in Control group (1.7 [1.4;2.1] μM vs 1.25 [0.9;1.78] μM, respectively; p=0.004) while no difference in serum concentration of Trp was observed between the two groups. Kyn/Trp ratio (IDO activity) was significantly higher in the CRC group than in Control group. At Day 7 serum concentrations of Trp, Kyn and the Kyn/Trp ratio were not statistically different between the two groups.

Conclusion: This study indicates that IDO activity is higher in patients with CRC compared with those without CRC. Surgical treatment impacts the IDO activity with a similar Kyn/Trp ratio in both groups. This study is the first step to larger studies to establish the Kyn/Trp ratio as a reliable serum marker of CRC.

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