alexa Mechanical Control of Mesenchymal Stem Cell Adipogenesi
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Mechanical Control of Mesenchymal Stem Cell Adipogenesis

Hillary Stoll1, Frederick G Hamel2,3, Jeong Soon Lee4, Ligyeom Ha4 and Jung Yul Lim4,5*

1Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA

2Departments of Internal Medicine and Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center (UNMC), Omaha, NE, 68198, USA

3Research Service (151), Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, 68105, USA

4Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA

5Graduate School of Dentistry, Kyung Hee University, Seoul, Korea

corresponding Author:
Jung Yul Lim
Department of Mechanical and Materials Engineering
University of Nebraska-Lincoln, NE 68588, USA
Tel: 1-402-472-2480
Fax: 1-402-472-1465
E-mail: [email protected]

Received Date: November 14, 2014; Accepted Date: January 05, 2015; Published Date: January 12, 2015

Citation: Stoll H, Hamel FG, Lee JS, Ha L, Lim JY (2015) Mechanical Control of Mesenchymal Stem Cell Adipogenesis. Endocrinol Metab Synd 4:152. doi:10.4172/2161-1017.1000152

Copyright: © 2015 Stoll H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Increased Mesenchymal Stem Cell (MSC) commitment and differentiation into adipocytes contributes to obesity. Other than dietary and biochemical factors, recent studies have begun to explore the role of mechanical signals in controlling MSC adipocytic commitment and differentiation. Several reported data suggest that by subjecting MSCs to certain mechanical stimuli, such as stretching, compression, and fluid shear, their adipogenesis could be inhibited or decreased. However, it is still very early to draw conclusions on the detailed mechanical regimens to optimally inhibit MSC adipogenesis and on the molecular pathways governing such adipogenesis-inhibitory mechanosensitive signaling. In this commentary, key data on the mechanical control of MSC adipogenesis and proposed molecular mechanisms will be highlighted and a future perspective in this new topic area will be provided.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords