Mechanical Control of Mesenchymal Stem Cell AdipogenesisHillary Stoll1, Frederick G Hamel2,3, Jeong Soon Lee4, Ligyeom Ha4 and Jung Yul Lim4,5*
- corresponding Author:
- Jung Yul Lim
Department of Mechanical and Materials Engineering
University of Nebraska-Lincoln, NE 68588, USA
E-mail: [email protected]
Received Date: November 14, 2014; Accepted Date: January 05, 2015; Published Date: January 12, 2015
Citation: Stoll H, Hamel FG, Lee JS, Ha L, Lim JY (2015) Mechanical Control of Mesenchymal Stem Cell Adipogenesis. Endocrinol Metab Synd 4:152. doi:10.4172/2161-1017.1000152
Copyright: © 2015 Stoll H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Increased Mesenchymal Stem Cell (MSC) commitment and differentiation into adipocytes contributes to obesity. Other than dietary and biochemical factors, recent studies have begun to explore the role of mechanical signals in controlling MSC adipocytic commitment and differentiation. Several reported data suggest that by subjecting MSCs to certain mechanical stimuli, such as stretching, compression, and fluid shear, their adipogenesis could be inhibited or decreased. However, it is still very early to draw conclusions on the detailed mechanical regimens to optimally inhibit MSC adipogenesis and on the molecular pathways governing such adipogenesis-inhibitory mechanosensitive signaling. In this commentary, key data on the mechanical control of MSC adipogenesis and proposed molecular mechanisms will be highlighted and a future perspective in this new topic area will be provided.