alexa Mechanism of Action of Nutraceuticals on Intestine to Ameliorate Glucose Homeostasis: Follow-up Studies by an In Situ Approach
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Mechanism of Action of Nutraceuticals on Intestine to Ameliorate Glucose Homeostasis: Follow-up Studies by an In Situ Approach

Bárbara Graziela Postal1, Samantha Manes Guesser1, Virgínia Demarchi Kappel1, Ana Paula Ruani2, Nicolas Suarez Zamorano1,3, Angela Machado de Campos4, Flávio Henrique Reginatto4, Moacir Geraldo Pizzolatti2, Daniela Ota Hisayasu Suzuki5 and Fátima Regina Mena Barreto Silva1*

1Department of Biochemistry, Biological Sciences Center, Federal University of Santa Catarina, Trindade Neighborhood, Cx Postal 5069, CEP: 88040-970 - Florianópolis, SC, Brazil

2Departamento of Chemistry, Center of Physical and Mathematical Sciences, Federal University of Santa Catarina, University Campus, Bairro Trinity Cx. Postal 5069, ZIP: 88,040 to 970 - Florianópolis, SC, Brazil

3Pierre and Marie Curie University, Sorbonne University, Paris 6, Place Jussieu - 75252 Paris Cedex 05, France

4Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil

5Department of Electrical Engineering, Institute of Biomedical Engineering, Federal University of Santa Catarina, University Campus, Trindade neighborhood, Florianópolis, SC, Brazil

*Corresponding Author:
Fátima Regina Mena Barreto Silva
Departamento de Bioquímica
Centro de CiênciasBiológicas
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
Tel: +55-48.3721.69.12
Fax: +55-48.3721.96.72
E-mail: [email protected]

Received date: March 28, 2014; Accepted date: April 11, 2014; Published date: April 14, 2014

Citation: Postal BG, Guesser SM, Kappel VD, Ruani AP, Zamorano NS, et al. (2014) Mechanism of Action of Nutraceuticals on Intestine to Ameliorate Glucose Homeostasis: Follow-up Studies by an In Situ Approach. J Cell Sci Ther 5:162. doi: 10.4172/2157-7013.1000162

Copyright: © 2014 Postal BG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Epidemiologic studies and clinical trials have suggested a correlation between dietary polyphenols and prevention of chronic diseases such as diabetes. The current study has been limited to the compounds previously studied by in vivo and in vitro experimental model concerned glucose homeostasis.

Objective:
Some selected compounds as myricitrin, quercetin, catechin, naringenin, caffeic acid, rutin, fukugetin, hispidulin, kaempferitrin and chlorogenic acid were investigated in sodium-glucose co-transporter activity in rat intestine through an in situ approach, compared with phlorizin, a classical competitive inhibitor of Na+-dependent glucose transport. Methods: For the in situ studies the intestine segments were uploaded with glucose solution, phlorizin and/or compounds and after 30 min the glucose was measured into the respective intestinal segment.
Results: Among the substances assayed, myricitrin, quercetin, catechin, naringenin, caffeic acid, rutin and fukugetin significantly reduced the glucose uptake by affecting the SGLT1 transporter activity measured in the presence of phlorizin. It worthwhile mentions that myricitrin at 10mM exhibited a per se inhibitory effect around 90% higher than that observed for phlorizin. Quercetin inhibited the glucose uptake in both concentrations used and exhibited an effect on glucose absorption as good as phlorizin at 10 mM. Catechin and caffeic acid (10 mM) in the presence of phlorizin potentiated the inhibitory effect of this compound on glucose uptake. Moreover, 10 mM naringenin showed a similar inhibitory effect of phlorizin. Additionally, rutin and fukugetin (10 mM) alone or in combination with phlorizin slightly reduced the glucose absorption.

Conclusion:
Based on these results, myricitrin, quercetin, catechin, naringenin, caffeic acid, rutin and fukugetin are able to regulate glucose absorption by acting in an intestinal target, SGLT1, contributing to ameliorate glucose homeostasis.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords