alexa Mechanism of Changes Balance Anaerobic Processes and Aerobic Processes in Cancer Metabolism Causing Warburg Effect Mechanism | OMICS International | Abstract
ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Mechanism of Changes Balance Anaerobic Processes and Aerobic Processes in Cancer Metabolism Causing Warburg Effect Mechanism

Ponizovskiy MR1,2*

1Herschelstrasse 33, 90443 Nuernberg, Germany

2Head of Laboratory Biochemistry and Toxicology, Kiev Regional p/n Hospital, Kiev, Ukraine

*Corresponding Author:
Ponizovskiy MR
             Herschelstrasse 33,90443 Nuernberg,Germany
Tel: (49911)-653-78-11
Fax: 0086 22 23346434
E-mail: [email protected]

Received Date: March 16, 2017; Accepted Date: March 21, 2017; Published Date: March 28, 2017

Citation: Ponizovskiy MR (2017) Mechanism of Changes Balance Anaerobic Processes and Aerobic Processes in Cancer Metabolism Causing Warburg Effect Mechanism. J Biomol Res Ther 6:150. doi: 10.4172/2167-7956.1000150

Copyright: © 2017 Ponizovskiy MR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Changes balance catabolic anaerobic exergonic processes of oxidative phosphorylation and catabolic aerobic exergonic processes of respiratory oxidation induce violation interaction between mitochondrial oxidative processes and nuclear proliferative function. Just the changes balance catabolic anaerobic processes and catabolic aerobic processes cause transition Pasteur Effect “incompatible glycolysis and aerobic oxidation” in norm into Warburg effect “aerobic glycolysis” of cancer metabolism. Normal Stationary State of balance anabolic endergonic processes and catabolic exergonic processes is mutated into Quasi-stationary pathologic State due to the shift balance anabolic processes and catabolic processes into excessive anabolic processes with partial suppression catabolic processes in cancer tissue. Considering Krebs tricarboxylic citric acids cycle as the link between anaerobic catabolic processes and aerobic catabolic processes, it was explained the mechanism destruction of this link in cancer tissue metabolism. Thus the partial suppression of catabolic anaerobic exergonic processes leads to misbalance between catabolic anaerobic exergonic processes of oxidative phosphorylation and catabolic aerobic exergonic processes of respiratory oxidation in cancer tissue. This misbalance is induced by the expressed excessive anabolic processes in cancer tissue. These processes promote survival cancer cells as Apoptosis Resistance and display “aerobic glycolysis” which characterizes Warburg effect mechanism. Taking into account role of Citric acids cycle in the mechanism of the misbalance between catabolic anaerobic processes and catabolic aerobic exergonic processes in cancer tissue, it was offered the method prevention supplementary new metastasis by up-to-date methods of cytotoxic chemotherapy

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version