Mechanism of Mitochondrial Dysfunction during Chronic FatigueRekik A Muluye1,2* and Yuhong Bian1
- *Corresponding Author:
- Rekik Ashebir Muluye
Tianjin University of Traditional Chinese Medicine, P.R.China
E-mail: [email protected]
Received date: March 22, 2017; Accepted date: April 25, 2017; Published date: April 27, 2017
Citation: Muluye RA, Bian Y (2017) Mechanism of Mitochondrial Dysfunction during Chronic Fatigue. Int J Phys Med Rehabil 5:405. doi: 10.4172/2329-9096.1000405
Copyright: © 2017 Muluye RA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A clinically defined condition characterized by persistent, severe, disabling fatigue lasting more than six months that is not reversed by sleep is regarded as chronic fatigue (CF). Fatigue is a complex phenomenon determined by several factors, including psychological health but at the biochemical level fatigue is related to the metabolic energy available to tissues and cells, mainly through mitochondrial respiration. Fatigue is the most common symptom of poorly functioning mitochondria. therefore dysfunction of these organelles may be the cause of the fatigue seen in CF. There is a great progress in the molecular understanding of mitochondrial disorder but the relation of mitochondrial dysfunction with CF and the underlying mechanism is not identified well in addition treatment of fatigue is still inadequate. In this review we try to summarize the relation between CF with mitochondrial dysfunction and determine the underline mechanism.