Mechanism of Polygonum bistorta and Zingiber roseum Against Toxicity
- *Corresponding Author:
- Deepak Kumar Mittal
School of Studies in Zoology, Jiwaji University
Gwalior - 474011 (MP), India
E-mail: [email protected]
Received date: September 27, 2013; Accepted date: January 08, 2014; Published date: January 17, 2014
Citation: Mittal DK, Jena AK, Joshi D (2014) Mechanism of Polygonum bistorta and Zingiber roseum Against Toxicity. J Drug Metab Toxicol 5:161. doi: 10.4172/2157-7609.1000161
Copyright: © 2014 Mittal DK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study was carried out to observe the hepatoprotective effect and antioxidant activity of the aqueous extract of the roots of Polygonum bistorta (PB) (100 mg/kg) and Zingiber roseum (ZR) (100 mg/kg) in rats treated with carbon tetrachloride (0.15 ml/kg, i.p.). Extract of PB and ZR at the tested doses restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione-S-transferase, superoxide dismutase and catalase enzymes significantly. The activities of MTT assay significantly recovered the damage towards normal. This study shows that Zingiber roseum has a more liver protective effect in comparison to Polygonum bistorta and against carbon tetrachloride- induced hepatotoxicity and possess antioxidant activities and extracts exhibited moderate anticancer activity towards cell viability at higher concentration.