alexa Mechanisms of Action of Herbal Cholagogues
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

Mechanisms of Action of Herbal Cholagogues

Nikolay A. Spiridonov*
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA
Corresponding Author : Nikolay A. Spiridonov
Division of Therapeutic Proteins
Center for Drug Evaluation and Research
US Food and Drug Administration
Bldg. 29A, Rm. 2B-06, 29 Lincoln Drive
Bethesda, MD 20892, USA
E-mail: [email protected]
Received June 07, 2011; Accepted June 13, 2012; Published June 16, 2012
Citation: Spiridonov NA (2012) Mechanisms of Action of Herbal Cholagogues. Med Aromat Plants 1:107. doi: 10.4172/2167-0412.1000107
Copyright: © 2012 Spiridonov NA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Plant secondary metabolic compounds with the cholagogue mode of action are important therapeutic agents for the treatment of cholestasis and hepatobiliary disorders. Herbal cholagogues target different components of the complex bile production and secretion system, and exert their action via diverse routes, such as cholecystokinin-dependent and independent gallbladder contraction, up-regulation of the bile acid synthesis, stimulation of the bile salt export pump, multidrug resistance protein transporter system, and osmotic bile flow.

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