Mechanisms of Chemoresistance in Human Ovarian Cancer at a GlanceMichelle X Liu, David W Chan* and Hextan YS Ngan
Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R.China
- *Corresponding Author:
- David W Chan
Department of Obstetrics and Gynaecology
L747 Laboratory Block, LKS Faculty of Medicine
21 Sassoon Road, Pokfulam, Hong Kong
Tel: (852) 2819-9367
Fax: (852) 2816-1947
E-mail: [email protected]
Received date: May 21, 2012; Accepted date: May 21, 2012; Published date: May 24, 2012
Citation: Liu MX, Chan DW, Ngan HYS (2012) Mechanisms of Chemoresistance in Human Ovarian Cancer at a Glance. Gynecol Obstet 2:e104. doi: 10.4172/2161-0932.1000e104
Copyright: © 2012 Liu MX, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ovarian cancer is one of the most deadly malignancies in women because of its poor prognosis and that a majority of patients are diagnosed at advanced stage. Therefore, chemotherapy becomes the most important treatment option in most ovarian cancer cases. However, chemoresistance in relapsed cases is the major obstacle for the clinical management of this disease. Mounting evidences have suggested the de novo (intrinsic) and acquired (extrinsic) chemoresistance are two major underlying mechanisms occurring in human cancers. The de novo chemoresistance is attributed to the existence of cancer stem cells, while the genetic and/or epigenetic alterations in dysregulation of oncogenes or tumor suppressor genes contribute to the acquired chemoresistance. In this review, we will summarize and discuss the recent findings of the above mechanisms in chemoresistance and particularly, we will focus on the significance of putative miRNAs expressions and their associated signaling regulations in the development of acquired chemoresistance in ovarian cancer.